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Table 1 Baseline characteristics of 357 patients with febrile urinary tract infection

From: Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women

 

Randomized (n = 200)

Not randomized (n = 157)

P valuec

Antibiotic treatment for 7 days (n = 97)

Antibiotic treatment for 14 days (n = 103)

Age (years)

60 (48–72)

61 (40–73)

63 (49–75)

0.277

Male sex

44 (45%)

42 (41%)

58 (37%)

0.247

Body mass index (kg/m2, mean, SD)

26.3 (5.2)

25.8 (4.5)

26.1 (4.9)

0.969

Urologic history

 Indwelling urinary catheter

3 (3%)

2 (2%)

12 (8%)

0.024

 Urinary tract disordera

28 (29%)

28 (27%)

52 (33%)

0.296

 Recurrent UTIb

19 (20%)

19/100 (19%)

47/147 (32%)

0.007

Comorbidity

 Diabetes mellitus

12 (12%)

17 (17%)

25 (16%)

0.709

 Malignancy

3 (3%)

5 (5%)

17 (11%)

0.012

 Heart failure

12 (12%)

6 (6%)

19 (12%)

0.340

 Cerebrovascular disease

5 (5%)

5 (5%)

13 (8%)

0.210

 Chronic renal insufficiency

3 (3%)

2 (2%)

10 (6%)

0.070

 COPD

10 (10%)

11 (11%)

23 (15%)

0.236

 Immunocompromised

3 (3%)

8 (8%)

14 (9%)

0.209

Signs and symptoms at presentation

 Presentation at emergency department

59 (61%)

68 (66%)

145 (92%)

<0.001

 Antibiotic pretreatment

23 (24%)

29 (28%)

56 (36%)

0.048

 Fever duration, hours

30 (15–48)

36 (20–60)

48 (19–96)

0.081

 Dysuria

82/95 (86%)

78/102 (77%)

102/145 (70%)

0.019

 Flank pain

57/96 (59%)

67/102 (66%)

91/144 (63%)

0.914

 Suprapubic pain

51/96 (53%)

48/100 (48%)

72/145 (50%)

0.876

 Perineal pain

4/96 (4%)

7/98 (7%)

8/140 (6%)

0.986

 Shaking chills within previous 24 hours

63/97 (65%)

60/101 (59%)

102/149 (70%)

0.256

 Temperature > 38 °C

66 (68%)

76 (74%)

121 (77%)

0.226

 Systolic blood pressure (mm Hg, mean, SD)

132 (19)

132 (22)

129 (20)

0.324

 Pulse rate (beats/minute)

93 (17)

94 (19)

97 (19)

0.360

Outpatient treatment

45 (46%)

45 (44%)

23 (15%)

<0.001

Positive urine culture

69 (71%)

68 (66%)

107 (68%)

0.944

Positive blood culture

20/88 (23%)

15/98 (15%)

45/153 (29%)

0.012

Positive urine and/or blood culture

75 (77%)

70 (68%)

118 (75%)

0.571

Initial intravenous dose(s) of antibiotics

48 (50%)

55 (53%)

133 (85%)

< 0.001

  1. Data presented as number (%) or median (IQR)
  2. COPD chronic obstructive pulmonary disease, UTI urinary tract infection
  3. aAny functional or anatomical abnormality of urinary tract except urinary catheter
  4. bThree or more UTIs in past 12 months or two or more UTIs in past 6 months
  5. cRandomized (both 7 and 14 days ciprofloxacin) vs. not-randomized patients