Randomized (n = 200) | Not randomized (n = 157) | P valuec | ||
---|---|---|---|---|
Antibiotic treatment for 7 days (n = 97) | Antibiotic treatment for 14 days (n = 103) | |||
Age (years) | 60 (48–72) | 61 (40–73) | 63 (49–75) | 0.277 |
Male sex | 44 (45%) | 42 (41%) | 58 (37%) | 0.247 |
Body mass index (kg/m2, mean, SD) | 26.3 (5.2) | 25.8 (4.5) | 26.1 (4.9) | 0.969 |
Urologic history | ||||
Indwelling urinary catheter | 3 (3%) | 2 (2%) | 12 (8%) | 0.024 |
Urinary tract disordera | 28 (29%) | 28 (27%) | 52 (33%) | 0.296 |
Recurrent UTIb | 19 (20%) | 19/100 (19%) | 47/147 (32%) | 0.007 |
Comorbidity | ||||
Diabetes mellitus | 12 (12%) | 17 (17%) | 25 (16%) | 0.709 |
Malignancy | 3 (3%) | 5 (5%) | 17 (11%) | 0.012 |
Heart failure | 12 (12%) | 6 (6%) | 19 (12%) | 0.340 |
Cerebrovascular disease | 5 (5%) | 5 (5%) | 13 (8%) | 0.210 |
Chronic renal insufficiency | 3 (3%) | 2 (2%) | 10 (6%) | 0.070 |
COPD | 10 (10%) | 11 (11%) | 23 (15%) | 0.236 |
Immunocompromised | 3 (3%) | 8 (8%) | 14 (9%) | 0.209 |
Signs and symptoms at presentation | ||||
Presentation at emergency department | 59 (61%) | 68 (66%) | 145 (92%) | <0.001 |
Antibiotic pretreatment | 23 (24%) | 29 (28%) | 56 (36%) | 0.048 |
Fever duration, hours | 30 (15–48) | 36 (20–60) | 48 (19–96) | 0.081 |
Dysuria | 82/95 (86%) | 78/102 (77%) | 102/145 (70%) | 0.019 |
Flank pain | 57/96 (59%) | 67/102 (66%) | 91/144 (63%) | 0.914 |
Suprapubic pain | 51/96 (53%) | 48/100 (48%) | 72/145 (50%) | 0.876 |
Perineal pain | 4/96 (4%) | 7/98 (7%) | 8/140 (6%) | 0.986 |
Shaking chills within previous 24 hours | 63/97 (65%) | 60/101 (59%) | 102/149 (70%) | 0.256 |
Temperature > 38 °C | 66 (68%) | 76 (74%) | 121 (77%) | 0.226 |
Systolic blood pressure (mm Hg, mean, SD) | 132 (19) | 132 (22) | 129 (20) | 0.324 |
Pulse rate (beats/minute) | 93 (17) | 94 (19) | 97 (19) | 0.360 |
Outpatient treatment | 45 (46%) | 45 (44%) | 23 (15%) | <0.001 |
Positive urine culture | 69 (71%) | 68 (66%) | 107 (68%) | 0.944 |
Positive blood culture | 20/88 (23%) | 15/98 (15%) | 45/153 (29%) | 0.012 |
Positive urine and/or blood culture | 75 (77%) | 70 (68%) | 118 (75%) | 0.571 |
Initial intravenous dose(s) of antibiotics | 48 (50%) | 55 (53%) | 133 (85%) | < 0.001 |