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Fig. 1 | BMC Medicine

Fig. 1

From: Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

Fig. 1

Type 1 (T1D) and type 2 diabetes (T2D) genetic risk scores (GRS) tested in latent autoimmune diabetes in adulthood (LADA) cases and controls. Weighted GRS for T1D (black) and T2D (red) were calculated by summing over all the risk alleles (T1D/T2D SNPs). The scores were tested in a 978 LADA cases and 1057 healthy controls; b 309 autoantibody-positive (glutamic acid decarboxylase autoantibodies (GADA) and insulinoma-associated antigen-2 autoantibodies (IA2A)) LADA cases and 1057 controls; c 669 GADA-only autoantibody positive. The ability of the GRS to discriminate between cases and controls was assessed by receiver and operator characteristic analysis. The area under the curve (AUC) was 0.667 and 0.565 for T1D and T2D, respectively, in the set with all LADA cases, 0.76 for T1D and 0.496 for T2D in the GADA, IA2A autoantibody-positive restricted set, and 0.623 for T1D, 0.597 for T2D in the GADA-only autoantibody-positive restricted set. A combination of T1D and T2D SNPs (green) had an AUC of 0.673 for all samples, 0.755 for the GADA+ IA2A+ restricted set, and 0.635 for the GADA-only restricted set

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BMC Medicine

ISSN: 1741-7015

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