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Table 1 Overview of model parameters

From: Assessing the efficiency of catch-up campaigns for the introduction of pneumococcal conjugate vaccine: a modelling study based on data from PCV10 introduction in Kilifi, Kenya

Model parameters

 

Contribution

No. of parameters

Prior

Posterior

    

Distribution

Mean

SD

Source

Median

CR

Study population

Age group size

Fixed

6 age groups

KHDSS [4]

 

Contact patterns

Fixed

6 × 6 age groups

KHDSS [5]

Carriage prevalence

Outcome

2 types × 6 age groups

KHDSS [11]

IPD

Outcome

2 types × 6 age groups

KHDSS [12]

Observed vaccine coverage

Fixed

27,040 (weekly age and time)

KHDSS [4]

Transmission dynamics

Clearance rates

Fixed

2 types × 4 age groups

   

KHDSS [15]

  
 

VE carriage (toddlers)

Fitted - prior

1

Normal

0.36

0.15

KHDSS [11]

0.56

0.41–0.72

VE IPD (infants)

Fitted - prior

1

Normal

0.80

0.1

[22]

0.86

0.67–0.99

Duration of protection (toddlers)

Fitted - prior

1

Normal

6 years

3

[23, 24]

5.50

2.05–11.01

Relative level of infant protection

Fitted - prior

1

Normal

1

0.1

Assumption

0.97

0.78–1.17

Competition parameter

Fitted - prior

1

Log-normal

0.15

0.15

[17, 18]

0.19

0.07–0.44

Susceptibility to infection

Fitted - no prior

2 types × 4 age groups

      

Invasiveness

Fitted - no prior

2 types × 4 age groups

     
  1. CR Credible range, VE Vaccine efficacy