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Fig. 4 | BMC Medicine

Fig. 4

From: Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

Fig. 4

TIM3+ γδ T cells are functionally inactive following stimulation with iRBCs and IPP. PBMCs from individuals living in malaria endemic areas were stimulated with iRBCs and then surface stained for TIM3 expression. Frequency of TIM3+ γδ T cells in (a) and (e) cytokine responders and non-responders and (b) and (f) in individuals with or without cytotoxically active γδ T cells after stimulation with iRBC or IPP (responders; filled squares and non-responders; open circles). Comparison of TIM3 expression by (c) and (g) cytokine-producing γδ T cells and (d) and (h) cytotoxic γδ T cells (TIM3+; filled circles and TIM3–; filled squares) in iRBC- or IPP-responding individuals. Statistical analysis was performed using (a, b, e, and f) Mann-Whitney tests and (c, d, g, and h) Wilcoxon matched pairs signed-rank test. *P < 0.05, **P < 0.01, ***P < 0.001

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BMC Medicine

ISSN: 1741-7015

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