Table 2 Mendelian randomisation studies using genetic risk scores (GRSs) to explore causality between uricaemia and cardiovascular outcomes; positive studies
From: Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options
Author year [ref] | GRS instrumental variable | No. of participants | Population | Account of pleiotropy | Main results |
|---|---|---|---|---|---|
Kleber 2015 [64] | 8 SNPs | 3315 | LURIC cohort German | No pleiotropy found | Association with cardiovascular mortality and sudden cardiac death |
Yan 2016 [65] | 17 SNPs 14 excluded | T2DM >3200 | China, Cross-sectional | Exclusion of 14 genes that are pleiotropic or in linkage disequilibrium | Association with diabetic macro-angiopathy |