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Table 4 The mediation role of mean arterial pressure at the time of retinal imaging in the association of gestational hypertensive disorders with retinal vascular calibers 6 years after index pregnancy (n = 3391)

From: Gestational hypertensive disorders and retinal microvasculature: the Generation R Study

 

Normotensive pregnancy (n = 3183)

Gestational hypertension (n = 145) Beta (95% CI)

P value

Pre-eclampsia (n = 63) Beta (95% CI)

P value

Retinal arteriolar caliber (SDS)

 Total effect

Ref

–0.20 (–0.35, –0.05)

0.01

–0.41 (–0.62, –0.21)

<0.001

 Direct effect

Ref

–0.01 (–0.14, 0.13)

0.94

–0.21 (–0.41, –0.02)

0.03

 Mediated effect

Ref

–0.20 (–0.26, –0.13)

<0.001

–0.20 (–0.29, –0.11)

<0.001

Retinal venular caliber (SDS)

 Total effect

Ref

0.22 (0.08, 0.36)

<0.001

0.08 (–0.09, 0.27)

0.39

 Direct effect

Ref

0.16 (0.02, 0.30)

0.02

0.03 (–0.14, 0.22)

0.76

 Mediated effect

Ref

0.06 (0.03, 0.09)

<0.001

0.05 (0.02, 0.09)

<0.001

  1. CI confidence interval, Ref reference, SDS standard deviation score, BMI body mass index
  2. Values are regression coefficients (95% CI) and are based on mediation analysis. Values are adjusted for maternal age at enrollment, ethnicity, educational level at intake, smoking at intake, and pre-pregnancy BMI. Additionally, we adjusted for retinal venular caliber when assessing the outcome retinal arteriolar caliber and vice versa