From: Gestational hypertensive disorders and retinal microvasculature: the Generation R Study
Normotensive pregnancy (n = 3183) | Gestational hypertension (n = 145) Beta (95% CI) | P value | Pre-eclampsia (n = 63) Beta (95% CI) | P value | |
---|---|---|---|---|---|
Retinal arteriolar caliber (SDS) | |||||
Total effect | Ref | –0.20 (–0.35, –0.05) | 0.01 | –0.41 (–0.62, –0.21) | <0.001 |
Direct effect | Ref | –0.01 (–0.14, 0.13) | 0.94 | –0.21 (–0.41, –0.02) | 0.03 |
Mediated effect | Ref | –0.20 (–0.26, –0.13) | <0.001 | –0.20 (–0.29, –0.11) | <0.001 |
Retinal venular caliber (SDS) | |||||
Total effect | Ref | 0.22 (0.08, 0.36) | <0.001 | 0.08 (–0.09, 0.27) | 0.39 |
Direct effect | Ref | 0.16 (0.02, 0.30) | 0.02 | 0.03 (–0.14, 0.22) | 0.76 |
Mediated effect | Ref | 0.06 (0.03, 0.09) | <0.001 | 0.05 (0.02, 0.09) | <0.001 |