Characteristics | Considered variations |
---|---|
Eligibility criteria | |
Population: | 50-74-30-15 |
Values arranged as | (eligibility criteria of the NLST clinical trial) |
age at begin smoking - age at quit smoking - minimum pack years - maximum years since quitting smoking | 55-80-30-15 |
(as recommended by the US Preventive Services Task Force (USPSTF) for lung screening with LDCT [2]) | |
50-75-15-9 | |
(less restrictive eligibility criteria, similar to the NELSON trial) | |
55-75-40-10 | |
(more restrictive eligibility criteria) [18] | |
Nodule management algorithm | Â |
NELSON-like | VDT cut = 400 days – V cut = 500 mm3 |
Scenario is characterised by the threshold value of the volume doubling time (VDT cut) and the cut-off volume (V cut) for cancer positive | (values of the NELSON clinical trial) |
VDT cut = 400 days – VDT cut = 300 mm3 | |
VDT cut = 400 days – VDT cut = 400 mm3 | |
VDT cut = 400 days – VDT cut = 750 mm3 | |
VDT cut = 300 days – VDT cut = 500 mm3 | |
VDT cut = 600 days – VDT cut = 500 mm3 | |
VDT cut = 300 days – omitting VDT cut a | |
VDT cut = 400 days – omitting VDT cut a | |
VDT cut = 600 days – omitting VDT cut a | |
V fup = 80 mm3 – VDT cut = 400 days – VDT cut = 500 mm3 b | |
NLST-like | Growth cut = 10% – D cut = 10 mm |
Scenario is characterised by the threshold value of the tumour growth and the diameter (D cut) for cancer positive | (values of the NLST clinical trial) |
Growth cut = 10% – D cut = 9 mm | |
Growth cut = 10% – D cut = 11 mm | |
Growth cut = 7.5% – D cut = 10 mm | |
Tumour growth (threshold growth, Growth cut) is defined as a percentage increase in diameter | Growth cut = 12.5% – D cut = 10 mm |
Growth cut = 7.5% – omitting D cut a | |
Growth cut = 10% – omitting D cut a | |
Growth cut = 12.5% – omitting D cut a | |
D fup = 5 mm – Growth = 10% – D cut = 10 mmb |