Table 2 Top 40 gene ontology (GO) biological processes associated with the 1400 genes differentially expressed between the short-term survivor (STS) and long-term survivor (LTS) samples of the learning set
From: A 25-gene classifier predicts overall survival in resectable pancreatic cancer
GO:BP TermsID | GO:BP Terms | N | P value | Status STS vs. LTS |
|---|---|---|---|---|
GO:0030198 | Extracellular matrix organization | 70 | 9.15 × 10–26 | Up |
GO:0007155 | Cell adhesion | 75 | 2.46 × 10–22 | Up |
GO:0022617 | Extracellular matrix disassembly | 35 | 2.70 × 10–18 | Up |
GO:0008544 | Epidermis development | 25 | 1.04 × 10–17 | Up |
GO:0030574 | Collagen catabolic process | 26 | 2.78 × 10–17 | Up |
GO:0006955 | Immune response | 50 | 1.44 × 10–16 | Up |
GO:0006954 | Inflammatory response | 52 | 2.34 × 10–16 | Up |
GO:0030199 | Collagen fibril organization | 19 | 6.76 × 10–16 | Up |
GO:0018149 | Peptide cross-linking | 10 | 1.23 × 10–10 | Up |
GO:0006935 | Chemotaxis | 22 | 2.34 × 10–10 | Up |
GO:0010951 | Negative regulation of endopeptidase activity | 23 | 6.65 × 10–10 | Up |
GO:0030216 | Keratinocyte differentiation | 14 | 3.24 × 10–9 | Up |
GO:0010466 | Negative regulation of peptidase activity | 8 | 1.47 × 10–8 | Up |
GO:0001501 | Skeletal system development | 22 | 2.51 × 10–8 | Up |
GO:0007160 | Cell-matrix adhesion | 19 | 1.30 × 10–7 | Up |
GO:0000278 | Mitotic cell cycle | 50 | 1.71 × 10–7 | Up |
GO:0008283 | Cell proliferation | 42 | 1.86 × 10–7 | Up |
GO:0031124 | Mrna 3-end processing | 600 | 2.19 × 10–7 | Up |
GO:0008284 | Positive regulation of cell proliferation | 45 | 3.26 × 10–7 | Up |
GO:0001525 | Angiogenesis | 32 | 3.31 × 10–7 | Up |
GO:0019228 | Neuronal action potential | 6 | 1.26 × 10–6 | Down |
GO:0007409 | Axonogenesis | 12 | 1.13 × 10–6 | Down |
GO:0007628 | Adult walking behavior | 7 | 1.09 × 10–6 | Down |
GO:0007212 | Dopamine receptor signaling pathway | 5 | 7.83 × 10–7 | Down |
GO:0006906 | Vesicle fusion | 10 | 4.63 × 10–7 | Down |
GO:0030073 | Insulin secretion | 9 | 5.27 × 10–8 | Down |
GO:0007274 | Neuromuscular synaptic transmission | 6 | 5.20 × 10–8 | Down |
GO:0007399 | Nervous system development | 27 | 1.44 × 10–8 | Down |
GO:0014047 | Glutamate secretion | 9 | 5.89 × 10–9 | Down |
GO:0007626 | Locomotory behavior | 15 | 4.46 × 10–9 | Down |
GO:0086010 | Membrane depolarization during action potential | 8 | 1.71 × 10–9 | Down |
GO:0031018 | Endocrine pancreas development | 12 | 1.16 × 10–9 | Down |
GO:0017158 | Regulation of calcium ion-dependent exocytosis | 10 | 9.94 × 10–10 | Down |
GO:0006112 | Energy reserve metabolic process | 20 | 4.05 × 10–11 | Down |
GO:0017157 | Regulation of exocytosis | 13 | 1.60 × 10–11 | Down |
GO:0006813 | Potassium ion transport | 15 | 3.94 × 10–12 | Down |
GO:0071805 | Potassium ion transmembrane transport | 17 | 1.97 × 10–13 | Down |
GO:0016079 | Synaptic vesicle exocytosis | 17 | 4.00 × 10–15 | Down |
GO:0007269 | Neurotransmitter secretion | 19 | 7.04 × 10–16 | Down |
GO:0007268 | Synaptic transmission | 66 | 2.33 × 10–37 | Down |