Table 2 Sensitivity and specificity of iPRM assay results for indicated study groups and subgroups

Sensitivity (n = 60)

All TB cases (n = 60)

51/60 (85.0%, 73.4–92.9)

12/12 (100%, 73.5–100)

38/47 (80.9%, 66.1–90.6)

 Culture-positive TB (n = 48)

43/48 (89.6%, 77.3–96.5)

12/12 (100%, 73.5–100)

30/36 (83.3%, 66.5–93.0)

  PTB only (N = 20)

18/20 (90.0%, 68.3–98.8)

6/6 (100%, 54.1–100)

12/14 (85.7%, 57.2–98.2)

  EPTB only (N = 7)

7/7 (100%, 59.0–100)

–

7/7 (100%, 59.0–100)

  PTB and EPTB (N = 21)

18/21 (85.7%, 63.7–97.0)

6/6 (100%, 54.1–100)

12/15 (80.0%, 59.5–98.3)

 Culture-negative TB (n = 12)

8/12 (66.7%, 34.9–90.1)

–

7/11 (60.0%, 26.2–87.8)

  PTB only (N = 10)

7/10 (70%, 34.8–93.3)

–

6/9 (66.7%, 29.0–96.3)

  EPTB only (N = 2)

1/2 (50%, 1.3–98.7)

–

1/2 (50.0%, 1.3–98.7)

Relapse TB cases

7/9 (77.8%, 47.4–99.7)

3/3 (100%, 29.2–100)

4/6 (66.7%, 28.4–99.5)

Specificity (n = 50)

All non-TB controls (n = 50)

44/50 (88.0%, 75.7–95.5)

 No history of previous TB (N = 35)

32/35 (91.4%, 76.9–98.2)

–

–

 History of previous TB (“cured TB,” N = 15)

12/15 (80.0%, 51.9–95.7)

–

–