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Table 2 Predictors of telomere length ranking between birth and young adulthood

From: Telomere tracking from birth to adulthood and residential traffic exposure

 

Multi variable model

Predictors

Change in ranking

95% CI

P value

Early-life covariates

 Placental telomere length, + IQR

–24.6

–29.4 to –19.9

<0.0001

 Newborn girls

9.9

0.8 to 19.0

0.04

 Birth weight, +IQR

1.3

–6.4 to 9.0

0.76

 Gestational age, +IQR

–3.4

–10.2 to 3.4

0.34

 Parental education level

–5.4

–10.5 to –0.4

0.04

 Smoking during pregnancy

–8.3

–23.0 to 6.4

0.27

 Residential distance to major road early-life, 2-fold change

8.7

1.2 to 16.1

0.03

Adult covariates

 Age, +1 year

–1.7

–3.2 to –0.3

0.03

 Smoking

–8.3

–17.1 to 0.5

0.07

 Gamma-glutamyl transferase, +IQR

–4.0

–7.4 to –0.7

0.02

  1. To examine telomere tracking over life we ranked telomere length at birth (based on placental telomere) and at adult life (based on buccal cell telomere length). We studied the difference in ranking, a negative difference in ranking between birth and young adulthood means a decline in ranking to 100 faster than the average of the population
  2. CI confidence interval, IQR interquartile range