Fig. 3

HBV integration identification. a The pipeline for HBV integration detection (detailed procedures for each step are described in Methods). The step indicated in the red box was the additional step in our pipeline. b The prediction accuracy (true positive rate) was evaluated through simulations with different HBV insertion allele frequency and coverage using simulated datasets. The performance of our pipeline was compared with results from Virusfinder2 across different coverage using simulated datasets of DNA (c) and RNA (d) sequencing. The detailed procedure of simulations is described in Additional file 3: Supplementary Materials and Methods