Fig. 5

Association of HBV integration events and tumor recurrence. a Host genes with HBV integration events are significantly enriched for tumor suppressor genes [45] and cancer census genes [46]. In particular, only fusion transcripts identified in non-neoplastic tissues of patients with recurrence were enriched for tumor suppressor genes. “n” is the number of overlapped genes with tumor suppressor genes and p is Fisher’s exact test P value. b Association of the number of fusion transcripts and tumor recurrence in non-neoplastic and tumor tissues of low and high liver fibrosis. c Association of the number of fusion transcripts and cccDNA per hepatocyte or d HBV replicative activity within non-neoplastic liver and tumor tissues.