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Table 1 Details of each outcome measure and data source

From: Rotavirus vaccine impact and socioeconomic deprivation: an interrupted time-series analysis of gastrointestinal disease outcomes across primary and secondary care in the UK

Data source

Population

Outcome

Denominator/offset

Age in months (m) or years (y)

Time period

Alder Hey Children's NHS Foundation Trust

RVGE hospitalisations. Alder Hey's footprint covers the majority of Merseyside children

Laboratory-confirmed rotavirus gastroenteritis. Rotavirus antigen detected by immunochromatography test (2005–2009) or by enzyme immunoassay (2002–2005 and 2009 onwards) in a faecal specimen of a child with acute gastroenteritis

Total hospitalisations per month by age group

0–14 y: < 12 m; 12–23 m; 24–59 m; 5–14 y

July 2002 to June 2016

Hospital Episode Statistics – admitted patient care

Merseyside residents attending any hospital in England

Hospitalisation for all-cause acute gastroenteritis. Identified by ICD-10 codes: A00–A09) or as non-infectious gastroenteritis (K52.9), in any diagnosis field

Yearly estimated age-specific population of Merseyside. Source: Office for National Statistics; accessed through Public Health England [16]

All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+

July 2000 to June 2016

Hospital Episode Statistics – accident and emergency

Merseyside residents attending three major emergency departments in Merseyside

Emergency department attendance for gastrointestinal conditions (AE diagnosis code 26); excluding subsequent admissions. Missing diagnosis data was imputed for one emergency department between November 2010 and March 2011

Total emergency department attendances (excluding subsequent admissions) per month by age group

All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+

July 2008 to June 2016

Walk-in centre attendance records

Attendances at walk-in centres in Wirral, covering an estimated resident population of 320,000

Walk-in centre attendance for infectious gastroenteritis. Read Codes: gastroenteritis – presumed infectious origin (A0812), diarrhoea of presumed infectious origin (A083); infantile viral gastroenteritis (A07y1); infectious gastroenteritis (A0803); enteritis due to rotavirus (A0762); and infectious diarrhoea (A082)

All walk-in centre attendances per month by age group

All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+

July 2011 to June 2016

GP records

Consultations at 136 GP practices in Merseyside, covering an estimated population of 790,000

Consultations for infectious gastroenteritis (Read Codes as above for walk-in centre)

Yearly estimated GP registered population by age group. Data were available from 2010 to 2016, therefore estimates for 2007/2008 and 2008/2009 were synthetically estimated using predictions from linear regression models. Source: Public Health England and participating GP practices

All ages: < 12 m; 12–23 m; 24–59 m; 5–14 y; 15–64 y; 65+

July 2007 to June 2016

  1. GP general practice, RVGE rotavirus gastroenteritis, AE accident and emergency