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Fig. 3 | BMC Medicine

Fig. 3

From: Metabolic characterization of menopause: cross-sectional and longitudinal evidence

Fig. 3

Cross-sectional (top panel) and longitudinal (bottom panel) associations of reproductive categories with 74 metabolic measures. Top panel: In the cross-sectional analysis, women were categorized into pre-menopausal, menopausal transition, and post-menopausal groups. Using pre-menopausal women as the reference group, the colors define the SD differences in each metabolite concentration between the other two groups and the reference group (Fig. 1b). Bottom panel: In the longitudinal analysis, women were categorized into six groups based on their baseline and follow-up reproductive status. Using those women who were pre-menopausal at both time points as the reference group, the colors illustrate the SD differences in the concentration change during the follow-up between the other five groups and the reference group (Fig. 1b). Cross-sectional and longitudinal associations were adjusted for baseline age. The metabolites are plotted in the same order as in Fig. 2. C cholesterol, DHA docosahexaenoic acid, FA fatty acids, HDL high-density lipoprotein, IDL intermediate-density lipoprotein, MUFA monounsaturated fatty acids, PL phospholipids, PUFA polyunsaturated fatty acids, SD standard deviation, TG triglycerides, VLDL very low-density lipoprotein

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