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Table 3 Median adult cause-specific chance-corrected concordance (%) for InSilicoVA and Tariff 2.0

From: Performance of InSilicoVA for assigning causes of death to verbal autopsies: multisite validation study using clinical diagnostic gold standards

  

InSilicoVA (Tariff 2.0 training)

Tariff 2.0

  

No HCE

HCE

No HCE

HCE

PHMRC cause

ICD10

Median

95% UI

Median

95% UI

Median

95% UI

Median

95% UI

Diarrhea/dysentery

A09

18.0

(16.8, 19.1)

21.5

(20.5, 22.5)

36.4

(35.1, 36.7)

38.5

(37.8, 39.3)

Tuberculosis

A16

23.2

(22.5, 24.7)

34.4

(32.8, 36.0)

42.2

(41.8, 43.1)

43.5

(43.1, 44.3)

AIDS

B24

13.2

(11.7, 14.9)

30.2

(29.1, 31.3)

44.3

(43.7, 45.1)

51.0

(50.5, 51.8)

Malaria

B54

30.1

(27.5, 31.3)

33.5

(31.3, 35.9)

42.3

(42.3, 43.8)

57.9

(55.2, 58.8)

Other infectious diseases

B99

3.5

(2.7, 4.4)

7.7

(6.6, 9.0)

6.3

(6.3, 6.7)

15.9

(15.5, 16.6)

Esophageal cancer

C15

61.5

(59.5, 63.6)

61.4

(58.8, 63.2)

69.1

(61.4, 69.1)

79.4

(79.4, 79.4)

Stomach cancer

C16

27.2

(25.2, 29.2)

26.3

(25.5, 28.4)

16.3

(16.3, 16.3)

29.2

(29.2, 35.6)

Colorectal cancer

C18

0.9

(−0.3, 1.9)

1.7

(1.0, 3.0)

5.9

(5.2, 9.3)

17.6

(17.6, 17.6)

Lung cancer

C34

35.9

(34.0, 37.4)

41.7

(38.9, 43.7)

32.6

(32.6, 34.1)

28.7

(28.7, 28.7)

Breast cancer

C50

40.4

(39.4, 42.0)

48.5

(47.4, 50.9)

69.8

(68.5, 70.6)

74.8

(74.8, 76.4)

Cervical cancer

C53

60.4

(58.8, 61.6)

65.7

(64.1, 67.7)

70.9

(70.1, 70.9)

75.8

(73.6, 76.2)

Prostate cancer

C61

31.8

(30.0, 33.9)

36.3

(33.3, 38.2)

48.5

(48.5, 48.5)

65.7

(62.5, 65.7)

Leukemia/lymphomas

C96

7.2

(5.9, 8.7)

16.6

(15.1, 17.6)

28.7

(26.8, 28.7)

34.9

(34.0, 36.6)

Diabetes

E14

13.0

(12.3, 14.5)

24.7

(23.5, 26.2)

46.9

(46.2, 47.7)

50.9

(50.2, 51.6)

Epilepsy

G40

16.2

(14.1, 18.0)

29.6

(26.5, 32.4)

48.5

(48.5, 48.5)

57.1

(57.1, 57.1)

Acute myocardial infarction

I21

27.1

(25.3, 28.7)

31.4

(31.2, 33.0)

39.6

(38.9, 40.2)

44.4

(43.5, 44.9)

Stroke

I64

43.6

(41.9, 44.5)

52.1

(51.1, 53.9)

47.1

(46.5, 47.7)

50.4

(49.8, 51.0)

Other cardiovascular diseases

I99

12.6

(11.6, 13.6)

19.4

(18.1, 20.5)

30.7

(30.3, 31.3)

37.3

(36.4, 38.0)

Pneumonia

J22

−0.5

(−0.8, 0.1)

8.4

(7.3, 9.5)

5.5

(5.2, 5.8)

15.2

(14.7, 15.5)

COPD

J33

25.6

(24.5, 27.3)

36.2

(34.1, 38.1)

38.2

(37.7, 39.6)

40.1

(38.7, 40.1)

Asthma

J45

9.6

(7.0, 11.6)

15.6

(14.1, 18.0)

58.8

(57.1, 65.7)

57.1

(57.1, 65.7)

Cirrhosis

K74

23.9

(22.6, 25.5)

39.1

(38.0, 40.5)

25.1

(24.4, 25.8)

51.2

(50.5, 51.9)

Renal failure

N19

−3.0

(−3.0, −3.0)

0.4

(−0.3, 1.4)

9.8

(9.5, 10.2)

28.9

(28.5, 29.6)

Maternal

O95

74.2

(72.2, 75.5)

77.1

(75.6, 78.2)

68.3

(67.5, 69.1)

68.0

(67.3, 68.4)

Other non-communicable diseases

R100

−3.0

(−3.0, −3.0)

−0.5

(−1.1, 0.2)

11.7

(11.3, 12.0)

14.6

(14.1, 15.0)

Road traffic

V89

36.9

(34.3, 38.1)

38.2

(36.3, 39.6)

77.3

(77.1, 78.5)

81.5

(81.5, 82.5)

Falls

W19

29.5

(27.6, 31.2)

34.1

(31.3, 35.5)

57.2

(56.9, 58.3)

59.3

(58.8, 60.4)

Drowning

W74

86.7

(85.3, 88.5)

82.7

(81.3, 83.3)

84.1

(83.5, 84.1)

81.3

(80.2, 84.1)

Fires

X09

24.0

(22.2, 26.2)

26.9

(25.1, 28.7)

70.6

(69.1, 72.5)

71.7

(69.1, 72.5)

Bite of venomous animal

X27

72.9

(70.1, 74.8)

74.2

(72.3, 76.1)

87.1

(87.1, 87.1)

80.7

(80.7, 80.7)

Poisonings

X49

21.2

(19.0, 22.7)

21.0

(19.4, 23.3)

34.4

(34.4, 34.4)

57.9

(55.8, 57.9)

Other injuries

X58

55.3

(52.4, 57.1)

65.6

(62.7, 66.3)

68.3

(68.3, 68.3)

72.3

(69.1, 72.3)

Suicide

X84

13.6

(12.4, 15.2)

19.1

(17.5, 20.5)

7.5

(6.9, 9.8)

9.8

(7.6, 10.3)

Homicide

Y09

26.6

(25.2, 27.9)

31.2

(29.5, 32.6)

73.0

(72.2, 73.0)

78.4

(77.9, 79.9)

  1. Table 3 shows the cause-specific chance-corrected concordance for adult data for InSilicoVA using an empirical probbase derived from training data mapped to the Tariff 2.0 format. Previously published Tariff 2.0 results are shown for comparison
  2. PHMRC Population Health Metrics Research Consortium, ICD International Classification of Diseases, HCE health care experience, UI uncertainty interval, COPD chronic obstructive pulmonary disease