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Table 3 Median adult cause-specific chance-corrected concordance (%) for InSilicoVA and Tariff 2.0

From: Performance of InSilicoVA for assigning causes of death to verbal autopsies: multisite validation study using clinical diagnostic gold standards

   InSilicoVA (Tariff 2.0 training) Tariff 2.0
   No HCE HCE No HCE HCE
PHMRC cause ICD10 Median 95% UI Median 95% UI Median 95% UI Median 95% UI
Diarrhea/dysentery A09 18.0 (16.8, 19.1) 21.5 (20.5, 22.5) 36.4 (35.1, 36.7) 38.5 (37.8, 39.3)
Tuberculosis A16 23.2 (22.5, 24.7) 34.4 (32.8, 36.0) 42.2 (41.8, 43.1) 43.5 (43.1, 44.3)
AIDS B24 13.2 (11.7, 14.9) 30.2 (29.1, 31.3) 44.3 (43.7, 45.1) 51.0 (50.5, 51.8)
Malaria B54 30.1 (27.5, 31.3) 33.5 (31.3, 35.9) 42.3 (42.3, 43.8) 57.9 (55.2, 58.8)
Other infectious diseases B99 3.5 (2.7, 4.4) 7.7 (6.6, 9.0) 6.3 (6.3, 6.7) 15.9 (15.5, 16.6)
Esophageal cancer C15 61.5 (59.5, 63.6) 61.4 (58.8, 63.2) 69.1 (61.4, 69.1) 79.4 (79.4, 79.4)
Stomach cancer C16 27.2 (25.2, 29.2) 26.3 (25.5, 28.4) 16.3 (16.3, 16.3) 29.2 (29.2, 35.6)
Colorectal cancer C18 0.9 (−0.3, 1.9) 1.7 (1.0, 3.0) 5.9 (5.2, 9.3) 17.6 (17.6, 17.6)
Lung cancer C34 35.9 (34.0, 37.4) 41.7 (38.9, 43.7) 32.6 (32.6, 34.1) 28.7 (28.7, 28.7)
Breast cancer C50 40.4 (39.4, 42.0) 48.5 (47.4, 50.9) 69.8 (68.5, 70.6) 74.8 (74.8, 76.4)
Cervical cancer C53 60.4 (58.8, 61.6) 65.7 (64.1, 67.7) 70.9 (70.1, 70.9) 75.8 (73.6, 76.2)
Prostate cancer C61 31.8 (30.0, 33.9) 36.3 (33.3, 38.2) 48.5 (48.5, 48.5) 65.7 (62.5, 65.7)
Leukemia/lymphomas C96 7.2 (5.9, 8.7) 16.6 (15.1, 17.6) 28.7 (26.8, 28.7) 34.9 (34.0, 36.6)
Diabetes E14 13.0 (12.3, 14.5) 24.7 (23.5, 26.2) 46.9 (46.2, 47.7) 50.9 (50.2, 51.6)
Epilepsy G40 16.2 (14.1, 18.0) 29.6 (26.5, 32.4) 48.5 (48.5, 48.5) 57.1 (57.1, 57.1)
Acute myocardial infarction I21 27.1 (25.3, 28.7) 31.4 (31.2, 33.0) 39.6 (38.9, 40.2) 44.4 (43.5, 44.9)
Stroke I64 43.6 (41.9, 44.5) 52.1 (51.1, 53.9) 47.1 (46.5, 47.7) 50.4 (49.8, 51.0)
Other cardiovascular diseases I99 12.6 (11.6, 13.6) 19.4 (18.1, 20.5) 30.7 (30.3, 31.3) 37.3 (36.4, 38.0)
Pneumonia J22 −0.5 (−0.8, 0.1) 8.4 (7.3, 9.5) 5.5 (5.2, 5.8) 15.2 (14.7, 15.5)
COPD J33 25.6 (24.5, 27.3) 36.2 (34.1, 38.1) 38.2 (37.7, 39.6) 40.1 (38.7, 40.1)
Asthma J45 9.6 (7.0, 11.6) 15.6 (14.1, 18.0) 58.8 (57.1, 65.7) 57.1 (57.1, 65.7)
Cirrhosis K74 23.9 (22.6, 25.5) 39.1 (38.0, 40.5) 25.1 (24.4, 25.8) 51.2 (50.5, 51.9)
Renal failure N19 −3.0 (−3.0, −3.0) 0.4 (−0.3, 1.4) 9.8 (9.5, 10.2) 28.9 (28.5, 29.6)
Maternal O95 74.2 (72.2, 75.5) 77.1 (75.6, 78.2) 68.3 (67.5, 69.1) 68.0 (67.3, 68.4)
Other non-communicable diseases R100 −3.0 (−3.0, −3.0) −0.5 (−1.1, 0.2) 11.7 (11.3, 12.0) 14.6 (14.1, 15.0)
Road traffic V89 36.9 (34.3, 38.1) 38.2 (36.3, 39.6) 77.3 (77.1, 78.5) 81.5 (81.5, 82.5)
Falls W19 29.5 (27.6, 31.2) 34.1 (31.3, 35.5) 57.2 (56.9, 58.3) 59.3 (58.8, 60.4)
Drowning W74 86.7 (85.3, 88.5) 82.7 (81.3, 83.3) 84.1 (83.5, 84.1) 81.3 (80.2, 84.1)
Fires X09 24.0 (22.2, 26.2) 26.9 (25.1, 28.7) 70.6 (69.1, 72.5) 71.7 (69.1, 72.5)
Bite of venomous animal X27 72.9 (70.1, 74.8) 74.2 (72.3, 76.1) 87.1 (87.1, 87.1) 80.7 (80.7, 80.7)
Poisonings X49 21.2 (19.0, 22.7) 21.0 (19.4, 23.3) 34.4 (34.4, 34.4) 57.9 (55.8, 57.9)
Other injuries X58 55.3 (52.4, 57.1) 65.6 (62.7, 66.3) 68.3 (68.3, 68.3) 72.3 (69.1, 72.3)
Suicide X84 13.6 (12.4, 15.2) 19.1 (17.5, 20.5) 7.5 (6.9, 9.8) 9.8 (7.6, 10.3)
Homicide Y09 26.6 (25.2, 27.9) 31.2 (29.5, 32.6) 73.0 (72.2, 73.0) 78.4 (77.9, 79.9)
  1. Table 3 shows the cause-specific chance-corrected concordance for adult data for InSilicoVA using an empirical probbase derived from training data mapped to the Tariff 2.0 format. Previously published Tariff 2.0 results are shown for comparison
  2. PHMRC Population Health Metrics Research Consortium, ICD International Classification of Diseases, HCE health care experience, UI uncertainty interval, COPD chronic obstructive pulmonary disease