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Fig. 3 | BMC Medicine

Fig. 3

From: Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Fig. 3

Naturally acquired human anti-CSP IgG correlates with the ability to promote C1q-fixation to CSP, despite individual differences in reactivity. Antibodies from malaria-exposed adults living in PNG (a; N = 116) and Kenya (b; N = 104) were tested for IgG and C1q-fixation to CSP by ELISA. Results were standardized to arbitrary units (AU) based on malaria-naïve negative controls from Melbourne (seropositivity defined as AU > 1, shown as dotted lines), and the mean and range of duplicates were graphed (mean only for scatter plots). The left panels show correlations between IgG and C1q-fixation to CSP (Spearman’s correlation coefficient, rho). The right panels show selected examples of IgG and C1q-fixation to CSP for individual serum samples from PNG donors (V7, V49, V51, V52, and V53) and Kenyan donors (AR18, AR22, AR28, AR36, and AR47). AU arbitrary units, CSP circumsporozoite protein, ELISA enzyme-linked immunosorbent assay, IgG immunoglobulin G, PNG Papua New Guinea

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