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Fig. 6 | BMC Medicine

Fig. 6

From: Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Fig. 6

Acquisition of C1q-fixing antibodies and total IgG to CSP and MSP2 antigens in malaria-exposed Kenyan children and adults. Kenyan children and adults (N = 75) were categorized into groups based on the median ages 0.5, 1, 2, 5, and 35 years (n = 11, n = 14, n = 18, n = 16, and n = 16, respectively). Samples were tested for C1q-fixation and total IgG to CSP (a) and MSP2 (b) by ELISA. Results were standardized to arbitrary units (AU) based on malaria-naive negative controls from Melbourne (seropositivity defined as AU > 1, shown as dotted lines), and the mean of duplicates were graphed along with the group median, interquartile range, and percentage of positive samples. Reactivity between two groups and more than two groups were compared using the Mann–Whitney U test and Kruskal–Wallis test, respectively. AU arbitrary units, CSP circumsporozoite protein, ELISA enzyme-linked immunosorbent assay, IgG immunoglobulin G, MSP2 Merozoite surface protein 2

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