Preschool-aged children (PSAC) | School-aged children (SAC) | |||||||
---|---|---|---|---|---|---|---|---|
Treatment arm | Treatment arm | |||||||
Characteristics | Placebo | 20 mg/kg | 40 mg/kg | 60 mg/kg | Placebo | 20 mg/kg | 40 mg/kg | 60 mg/kg |
42 | 40 | 44 | 44 | 38 | 46 | 46 | 44 | |
Female N (%) | 23 (54.8) | 21 (52.5) | 20 (45.5) | 27 (61.4) | 23 (60.5) | 25 (54.3) | 25 (54.3) | 25 (56.8) |
Age, years; median | 4 | 4 | 4 | 4 | 9 | 8 | 8 | 9 |
[IQR] | [2–5] | [2–5] | [2–5] | [2–5] | [6–13] | [6–13] | [6–14] | [6–13] |
Weight, kg; median | 15 | 15 | 15 | 15 | 22 | 22 | 24 | 22 |
[IQR] | [10–21] | [11–19] | [11–19] | [11–18] | [18–35] | [18–33] | [18–38] | [18–40] |
Height, cm; median | 97 | 98 | 101 | 100 | 125 | 125 | 125 | 124 |
[IQR] | [80–117] | [83–115] | [84–116] | [83–114] | [109–141] | [114–139] | [113–149] | [112–150] |
Haemoglobin (g/dL); median | 10.5 | 11.0 | 10.9 | 10.9 | 11.4 | 11.2 | 11.7 | 11.6 |
[IQR] | [9.1–13.2] | [9.1–12.8] | [8.8–12.5] | [8.5–12.9] | [9.7–13.7] | [9.9–12.4] | [9.7–12.8] | [10.1–13.5] |
Infection intensity N (%) | ||||||||
Light | 36 (85.7) | 38 (95.0) | 38 (86.4) | 40 (90.9) | 27 (71.1) | 35 (76.1) | 36 (78.3) | 33 (75.0) |
Heavy | 6 (14.3) | 2 (5.0) | 6 (13.6) | 4 (9.1) | 11 (28.9) | 11 (23.9) | 10 (21.7) | 11 (25.0) |
Co-infections N (%) | ||||||||
S. mansoni | 0 (0.0) | 0 (0.0) | 1 (2.3) | 1 (2.3) | 0 (0.0) | 1 (2.2) | 1 (2.2) | 0 (0.0) |
Plasmodium falciparum | 1 (2.4) | 0 (0.0) | 1 (2.3) | 0 (0.0) | 1 (2.6) | 4 (8.7) | 2 (4.3) | 3 (6.8) |
(based on thin/thick smear) |