Table 1 WHO Zika virus vaccine pipeline: in human trials (last updated September 2017 [29])
From: Zika vaccines and therapeutics: landscape analysis and challenges ahead
Platform | Candidate vaccine | Immunogen | Adjuvant type | Replicating virus | Registry ID | Trial status | Sponsor name | Sponsor type | Phase | Study start date | Age | Sample size | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA | GLS-5700 | prM/E | None | No | Open, not recruiting | GeneOne Life Science, Inc./Inovio Pharmaceuticals | Industry | Phase 1 | 1/7/16 | Adult | 40 | United States of America, Canada | |
Open, recruiting | GeneOne Life Science, Inc./Inovio Pharmaceuticals | Industry | Phase 1 | 1/8/16 | Adult | 160 | Puerto Rico | ||||||
Peptide | AGS-v | Mosquito salivary proteins | Â | No | Open, recruiting | NIH | Government | Phase 1 | 9/2/17 | Adult | 60 | United States of America | |
Recombinant viral vector | MV-Zika | prM/E | None | Yes | Open, recruiting | Themis Bioscience | Industry | Phase 1 | 4/4/17 | Adult | 48 | Austria | |
mRNA | mRNA-1325 | prM/E | None | No | Open, recruiting | Moderna Therapeutics | Industry | Phase 2 | 1/12/16 | Adult | 90 | United States of America | |
DNA | VRC-ZKADNA085–00-VP or VRC-ZKADNA090–00-VP | prM/E | None | No | Open, not recruiting | NIAID | Government | Phase 1 | 11/7/16 | Adult | 120 | United States of America | |
Open, recruiting | NIAID | Government | Phase 1 | 8/12/16 | Adult | 50 | United States of America | ||||||
Open, recruiting | NIAID | Government | Phase 2 | 29/3/17 | Child, Adult | 2500 | United States of America, Puerto Rico | ||||||
Inactivated whole target organism | ZIKV PIV | Full genome | Aluminum | No | Open, recruiting | NIAID | Government | Phase 1 | 1/11/16 | Adult | 75 | United States of America | |
Open, recruiting | NIAID | Government | Phase 1 | 14/10/16 | Adult | 90 | United States of America | ||||||
Open, recruiting | BIDMC | Academic | Phase 1 | 1/10/16 | Adult | 48 | United States of America | ||||||
Open, recruiting | NIAID | Government | Phase 1 | 24/2/17 | Adult | 90 | Puerto Rico | ||||||
Inactivated whole target organism | BBV121 | Full genome | Aluminum | No | CTRI/2017/05/008539 | Open, recruiting | Bharat Biotech International Ltd., India | Industry | Phase 1 | 1/6/17 | Adult | 48 | India |