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Table 2 Main results of Mendelian randomisation analysis using individual level data

From: Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

Cases/controls

Causal estimate (odds ratio)b (95% CI)

Overall estimatec

P value

P het d

Scotland 1

SOCCS/GS

Croatia

SOCCS/LBC

UK biobank

932/942

4551/8804

689/441

461/1444

3301/11382

Univariable model

 Weighted score

1.92 (0.36–10.27)

0.84 (0.44–1.62)

3.69 (0.41–33.34)

0.59 (0.09–3.99)

0.67 (0.33–1.38)

0.85 (0.55–1.33)

0.481

0.531

 Unweighted score

2.20 (0.30–16.19)

0.89 (0.41–1.93)

10.71 (0.71–161.41)

1.02 (0.11–9.84)

0.85 (0.36–1.96)

1.03 (0.61–1.73)

0.920

0.440

Multivariable modela

 Weighted score

6.85 (0.77–60.81)

0.63 (0.24–1.67)

3.82 (0.41–35.23)

0.57 (0.08–3.87)

0.87 (0.44–1.73)

1.03 (0.51–2.07)

0.931

0.227

 Unweighted score

4.70 (0.46–48.41)

0.65 (0.22–1.88)

11.21 (0.76–164.33)

0.93 (0.10–8.66)

0.81 (0.38–1.75)

1.12 (0.51–2.45)

0.785

0.222

  1. aMultivariable regression model adjusted by age, sex and BMI for Scotland 1, SOCCS/GS and UK biobank, age and sex for Croatia, sex for LBC.MD
  2. bChange in CRC risk per unit log-transformed 25-OHD (nmol/L)
  3. cOverall estimates were obtained by meta-analyses under random-effect model
  4. dPhet, P values of χ2 Q test for heterogeneity
  5. 25-OHD 25-hydroxyvitamin D, CI confidence interval, CRC colorectal cancer, GRS genetic risk score, LBC Lothian Birth Cohort, SOCCS Scotland Colorectal Cancer Study