N | NASH | Non-NASH | All |
---|---|---|---|
43 | 24 | 67 | |
Demographic | |||
Male, n (%) | 16 (37.2%) | 6 (25.0%) | 22 (32.8%) |
White, n (%) | 31 (77.5%) | 19 (82.6%) | 50 (79.4%) |
Age mean ± SD | 47.233 ± 10.254 | 45.083 ± 10.746 | 46.463 ± 10.403 |
BMI, kg/m2 | 48.921 ± 10.552 | 48.745 ± 9.200 | 48.856 ± 10.001 |
Clinical and biochemical | |||
Diabetes, n (%) | 28 (65.1%) | 8 (33.3%)* | 36 (53.7%) |
Hypertension, n (%) | 30 (73.2%) | 14 (58.3%) | 44 (67.7%) |
ALT, μ/L | 51.214 ± 34.985 | 34.042 ± 18.320* | 44.970 ± 30.985 |
AST, μ/L | 40.619 ± 24.883 | 23.375 ± 12.968*** | 34.348 ± 22.802 |
Bilirubin, mg/dL | 0.544 ± 0.040 | 0.383 ± 0.034** | 0.486 ± 0.030 |
Albumin, g/dL | 4.012 ± 0.114 | 4.127 ± 0.067 | 4.052 ± 0.078 |
Glucose, mg/dL | 125.268 ± 6.310 | 111.130 ± 8.946 | 120.188 ± 5.193 |
Total cholesterol, mg/dL | 175.025 ± 6.628 | 197.000 ± 8.732 | 183.266 ± 5.407 |
LDL, mg/dL | 97.811 ± 6.199 | 120.043 ± 8.859 | 106.333 ± 5.259 |
HDL, mg/dL | 40.667 ± 1.639 | 47.208 ± 2.438** | 43.159 ± 1.422 |
TGA, mg/dL | 172.103 ± 13.111 | 161.391 ± 23.062 | 168.129 ± 11.788 |
Histological featuresa | |||
Fat (1,2) vs. (3,4) | 14 (32.6%) | 5 (20.8%) | 19 (28.4%) |
Inflammation | |||
Portal inflammation (0.1) vs. (≥ 2) | 15 (34.9%) | 6 (25.0%) | 21 (31.3%) |
Kupffer cells (0.1) vs. (≥ 2) | 11 (25.6%) | 1 (4.2%)* | 12 (17.9%) |
PMN cells (0.1) vs. (≥ 2) | 5 (11.6%) | 0 (0.0%) | 5 (7.5%) |
Lymphocytes (0.1) vs. (≥ 2) | 26 (60.5%) | 6 (25.0%)** | 32 (47.8%) |
Fibrosis | |||
Pericellular fibrosis (0.1) vs. (≥ 2) | 28 (65.1%) | 0 (0.0%)*** | 28 (41.8%) |
Portal fibrosis (0.1) vs. (≥ 2) | 28 (65.1%) | 7 (29.2%)** | 35 (52.2%) |
Bridging fibrosis and cirrhosis | 14 (32.6%) | 0 (0.0%)*** | 14 (20.9%) |
Apoptosis | |||
Focal necrosis (0) vs. (1,2,3) | 20 (46.5%) | 5 (20.8%)* | 25 (37.3%) |
Mallory–Denk bodies (0) vs. (1,2,3) | 12 (27.9%) | 0 (0.0%)** | 12 (17.9%) |
Ballooning degeneration (0) vs. (1,2,3) | 24 (55.8%) | 0 (0.0%)*** | 24 (35.8%) |
Apoptotic bodies (0) vs. (1,2,3) | 4 (9.3%) | 0 (0.0%) | 4 (6.0%) |
Collagen percentage | 4.708 ± 3.283 | 2.794 ± 1.736* | 4.040 ± 2.970 |
Fat percentage | 18.645 ± 8.474 | 12.906 ± 7.552** | 16.641 ± 8.559 |