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Table 1 Demographic, clinical, and biochemical characteristics of the study cohort

From: An exploratory study examining how nano-liquid chromatography–mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease

N

NASH

Non-NASH

All

43

24

67

Demographic

 Male, n (%)

16 (37.2%)

6 (25.0%)

22 (32.8%)

 White, n (%)

31 (77.5%)

19 (82.6%)

50 (79.4%)

 Age mean ± SD

47.233 ±  10.254

45.083 ±  10.746

46.463 ±  10.403

 BMI, kg/m2

48.921 ±  10.552

48.745 ±  9.200

48.856 ±  10.001

Clinical and biochemical

 Diabetes, n (%)

28 (65.1%)

8 (33.3%)*

36 (53.7%)

 Hypertension, n (%)

30 (73.2%)

14 (58.3%)

44 (67.7%)

 ALT, μ/L

51.214 ± 34.985

34.042 ± 18.320*

44.970 ±  30.985

 AST, μ/L

40.619 ± 24.883

23.375 ± 12.968***

34.348 ±  22.802

 Bilirubin, mg/dL

0.544 ± 0.040

0.383 ±  0.034**

0.486 ±  0.030

 Albumin, g/dL

4.012 ±  0.114

4.127 ±  0.067

4.052 ±  0.078

 Glucose, mg/dL

125.268 ± 6.310

111.130 ± 8.946

120.188 ± 5.193

 Total cholesterol, mg/dL

175.025 ± 6.628

197.000 ± 8.732

183.266 ± 5.407

 LDL, mg/dL

97.811 ± 6.199

120.043 ± 8.859

106.333 ± 5.259

 HDL, mg/dL

40.667 ± 1.639

47.208 ± 2.438**

43.159 ± 1.422

 TGA, mg/dL

172.103 ± 13.111

161.391 ±  23.062

168.129 ±  11.788

Histological featuresa

Fat (1,2) vs. (3,4)

14 (32.6%)

5 (20.8%)

19 (28.4%)

Inflammation

 Portal inflammation (0.1) vs. (≥ 2)

15 (34.9%)

6 (25.0%)

21 (31.3%)

 Kupffer cells (0.1) vs. (≥ 2)

11 (25.6%)

1 (4.2%)*

12 (17.9%)

 PMN cells (0.1) vs. (≥ 2)

5 (11.6%)

0 (0.0%)

5 (7.5%)

 Lymphocytes (0.1) vs. (≥ 2)

26 (60.5%)

6 (25.0%)**

32 (47.8%)

Fibrosis

 Pericellular fibrosis (0.1) vs. (≥ 2)

28 (65.1%)

0 (0.0%)***

28 (41.8%)

 Portal fibrosis (0.1) vs. (≥ 2)

28 (65.1%)

7 (29.2%)**

35 (52.2%)

 Bridging fibrosis and cirrhosis

14 (32.6%)

0 (0.0%)***

14 (20.9%)

Apoptosis

 Focal necrosis (0) vs. (1,2,3)

20 (46.5%)

5 (20.8%)*

25 (37.3%)

 Mallory–Denk bodies (0) vs. (1,2,3)

12 (27.9%)

0 (0.0%)**

12 (17.9%)

 Ballooning degeneration (0) vs. (1,2,3)

24 (55.8%)

0 (0.0%)***

24 (35.8%)

 Apoptotic bodies (0) vs. (1,2,3)

4 (9.3%)

0 (0.0%)

4 (6.0%)

Collagen percentage

4.708 ± 3.283

2.794 ± 1.736*

4.040 ± 2.970

Fat percentage

18.645 ± 8.474

12.906 ± 7.552**

16.641 ± 8.559

  1. a Histopathological features were grouped by scores according to none, mild to moderate, or severe according to the hepatopathologist scoring as shown beside each variable
  2. *p < 0.05, **p < 0.01, ***p < 0.001
  3. ALT alanine aminotransferase, AST aspartate aminotransferase, BMI body mass index, HDL high density lipoprotein, LDL low density lipoprotein, NASH non-alcoholic steatohepatitis, PMN polymorphonuclear cells, SD standard deviation, TGA triglycerides