Fig. 6
In vitro drug sensitivity profile of the ART-R240 strain. In vitro dose–response curves, with 95% CI error bands, of the ART-R240 strain (red) to (a) dihydroartemisinin (DHA), (b) amodiaquine, (c) mefloquine, (d) chloroquine, (e) quinine, (f) halofantrine, (g) lumefantrine, and (h) pyrimethamine are shown and compared to the sensitive progenitor strain (ART-S) used as a control in each experiment (black). Results were reproducible in several independent experiments. Mean IC50 values (nM) are indicated in parentheses. The probability (p) of these IC50 values being from curves measured using the same strain of parasite, as determined by the extra sum-of-squares F test, are shown for each drug