Fig. 3

Lymphoproliferative responses to homologous (P. falciparum 7G8) and heterologous (P. falciparum NF54 and P. knowlesi) pRBC in study participants inoculated with a single dose of a 3 × 10⁷P. falciparum 7G8 pRBC treated with 50 nM (group A) or b 200 nM (group B) TF-A. Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples collected at different time points post-inoculation and cryopreserved. Following thawing, PBMCs were incubated with parasitised red blood cells (pRBC) or unparasitised red blood cells (uRBC) for 7 days; the last 18 h with ³[H] thymidine. Proliferation of PBMCs was estimated by ³[H] thymidine incorporation. Data represents mean ± SEM for each time point (tested in triplicate). CPM: counts per minutes. Delta CPM indicates that responses to pRBC were corrected against responses to uRBC. The day 28 samples for P4 and P6 were not available for testing against P. falciparum NF54 and P. knowlesi