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Table 1 Baseline characteristics of study participants by intervention group and baseline IL-6 level

From: Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial

 

Physical activity

Health education

Higher IL-6 subgroupa(n = 321)

Lower IL-6 subgroupa(n = 323)

All

n = 644

Higher IL-6 subgroupa(n = 331)

Lower IL-6 subgroupa(n = 323)

All

n = 654

Age, years, mean (SD)

78.9 ± 5.3

78.2 ± 5.1

78.6 ± 5.2

79.1 ± 5.2

79.1 ± 5.3

79.1 ± 5.3

 ≥ 80 years

133 (41.4)

129 (39.9)

262 (40.7)

144 (43.5)

146 (45.2)

290 (44.3)

Women

203 (63.2)

217 (67.2)

420 (65.2)

204 (61.6)

232 (71.8)

436 (66.7)

Education

 ≤ High school

121 (37.7)

125 (38.8)

246 (38.3)

111 (33.6)

113 (35.1)

224 (34.4)

 College

136 (42.4)

121 (37.6)

257 (40.0)

136 (41.2)

129 (40.1)

265 (40.6)

 Post graduate

64 (19.9)

76 (23.6)

140 (21.8)

83 (25.2)

80 (24.8)

163 (25.0)

Ethnicity/race

 White

245 (76.3)

242 (74.9)

487 (75.6)

260 (78.5)

256 (79.3)

516 (78.9)

 African American

59 (18.4)

61 (18.9)

120 (18.6)

54 (16.3)

39 (12.1)

93 (14.2)

 others

17 (5.3)

20 (6.2)

37 (5.7)

17 (5.1)

28 (8.7)

45 (6.9)

Living alone

140 (43.6)

148 (45.8)

288 (44.7)

172 (52.0)

153 (47.4)

325 (49.7)

CES-D score, mean (SD)

8.0 ± 7.0

8.4 ± 8.0

8.2 ± 7.5

8.9 ± 8.0

8.7 ± 7.9

8.8 ± 7.9

Body mass index, kg/m2, mean (SD)

31.0 ± 6.0

29.4 ± 5.4

30.2 ± 5.7

31.8 ± 6.4

28.8 ± 5.4

30.3 ± 6.1

SPPB score, mean (SD)

7.4 ± 1.7

7.5 ± 1.5

7.4 ± 1.6

7.2 ± 1.6

7.4 ± 1.6

7.3 ± 1.6

 SPPB = 8 or 9

174 (54.2)

192 (59.4)

366 (56.8)

176 (53.2)

181 (56.0)

357 (54.6)

History of hypertension

243 (75.7)

215 (66.6)

458 (71.1)

246 (74.3)

222 (68.7)

468 (71.6)

History of diabetes

86 (26.8)

77 (23.8)

163 (25.3)

99 (29.9)

70 (21.7)

169 (25.8)

History of cardiovascular disease

27 (8.4)

17 (5.3)

44 (6.8)

32 (9.7)

19 (5.9)

51 (7.8)

History of stroke

29 (9.0)

21 (6.5)

50 (7.8)

17 (5.1)

25 (7.7)

42 (6.4)

  1. Values are numbers (percentages) unless stated otherwise. The 1298 participants who had baseline data on both cognitive frailty and IL-6 were included
  2. SD standard deviation, CES-D Center for Epidemiologic Studies-Depression scale, SPPB Short Physical Performance Battery, IL-6 interleukin-6
  3. aThe cutoff point for categorizing IL-6 subgroups was 3.31 pg/mL (median value) in both physical activity and health education groups