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Table 1 Total number of studies and participants per antimalarial drug, with number of studies including children and pregnant women

From: The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review

Drug Total number of studies Total number of participants who had drug Total number of participants who had ECGs Total number of studies which included children Total number of studies which included pregnant women Total number of studies which included pharmacokinetic analysis
Quinine 51 2611 2320 18 1 19
Mefloquine 45 7874 3099 13 2 19
Lumefantrine 39 5703 4787 19 3 19
Piperaquine 24 15,224 5083 7 1 12
Halofantrine 22 822 774 7 0 10
Chloroquine 17 1207 1076 6 0 10
Sulfadoxine-pyrimethamine 14 1288 695 4 2 5
Amodiaquine 10 569 452 2 1 8
Primaquine 7 150 150 0 0 4
  1. Forty-nine studies evaluated more than one of the drugs included in this review. These articles have been included under each of the appropriate drugs for analysis