Table 2 Most common adverse events
|  | Grade 1–2 | Grade 3 | Grade 4 | |||
|---|---|---|---|---|---|---|
n | % | n | % | n | % | |
Hematologic | ||||||
 Neutropenia | 10 | 12.0 | 19 | 22.9 | 9 | 10.8 |
 Anemia | 24 | 28.9 | 4 | 4.8 | 0 | 0.0 |
 Thrombocytopenia | 1 | 1.2 | 0 | 0.0 | 0 | 0.0 |
 Febrile neutropenia | 0 | 0.0 | 4 | 4.8 | 1 | 1.2 |
Non-hematologic | ||||||
 Increased ALT concentration | 1 | 1.2 | 0 | 0.0 | 0 | 0.0 |
 Increased AST concentration | 1 | 1.2 | 0 | 0.0 | 0 | 0.0 |
 Asthenia/Fatigue | 61 | 73.5 | 11 | 13.3 | 0 | 0.0 |
 Nausea | 46 | 55.4 | 4 | 4.8 | 0 | 0.0 |
 Diarrhea | 63 | 75.9 | 6 | 7.2 | 0 | 0.0 |
 Vomiting | 28 | 33.8 | 1 | 1.2 | 0 | 0.0 |
 Mucositis | 44 | 53.0 | 8 | 9.6 | 0 | 0.0 |
 Peripheral edema | 2 | 2.4 | 0 | 0.0 | 0 | 0.0 |
 Peripheral sensory neuropathy | 15 | 18.1 | 5 | 6.0 | 0 | 0.0 |
 Dry skin | 11 | 13.2 | 0 | 0.0 | 0 | 0.0 |
 Left ventricular dysfunction | 2 | 2.4 | 1 | 1.2 | 0 | 0.0 |