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Table 3 Reproductive outcomes per embryo transfer

From: Effect of body mass index on pregnancy outcomes in a freeze-all policy: an analysis of 22,043 first autologous frozen-thawed embryo transfer cycles in China

Characteristics

Underweight (< 18.5 kg/m2)

P value

Normal weight (18.5–22.9 kg/m2)

Overweight (23–27.4 kg/m2)

P value

Obese (≥ 27.5 kg/m2)

P value

Implantation rate

1738/4790(36.3)

 

9397/25,076(37.5)

3522/9650(36.5)

 

806/2283 (35.3)

 

 OR (95% CI)

0.95(0.89 1.01)

0.119

Reference

0.96(0.91 1.01)

0.092

0.91(0.83 0.99)

0.040

 AOR (95% CI)

0.91(0.85 0.96)

0.002

Reference

0.95(0.90 0.99)

0.029

0.80(0.73 0.87)

< 0.001

Biochemical pregnancy rate

1454/2527(57.5)

 

7855/13,224(59.4)

2959/5079(58.3)

 

673/1213(55.5)

 

 OR (95% CI)

0.93(0.86 1.01)

0.081

Reference

0.95(0.89 1.02)

0.160

0.85(0.76 0.96)

0.008

 AOR (95% CI)

0.90(0.82 0.98)

0.017

Reference

0.96(0.89 1.02)

0.185

0.83(0.74 0.94)

0.003

Clinical pregnancy rate

1315/2527(52.0)

 

7106/13,224(53.7)

2671/5079(52.6)

 

592/1213(48.8)

 

 OR (95% CI)

0.93(0.86 1.02)

0.117

Reference

0.96(0.90 1.02)

0.164

0.82(0.73 0.92)

0.001

 AOR (95% CI)

0.91(0.83 0.99)

0.028

Reference

0.96(0.90 1.02)

0.201

0.81(0.71 0.91)

< 0.001

Multiple pregnancy rate

418/2527(16.5)

 

2255/13,224(17.1)

839/5079(16.5)

 

208/1213(17.1)

 

 OR (95% CI)

0.96(0.86 1.08)

0.531

Reference

0.96(0.88 1.05)

0.389

1.01(0.86 1.18)

0.933

 AOR (95% CI)

0.93(0.83 1.05)

0.236

Reference

0.96(0.88 1.05)

0.411

0.99(0.84 1.17)

0.910

Miscarriage rate

147/1315(11.2)

 

837/7106(11.8)

387/2671(14.5)

 

112/592(18.9)

 

 OR (95% CI)

0.94(0.78 1.14)

0.534

Reference

1.27(1.12 1.45)

< 0.001

1.75(1.41 2.17)

< 0.001

 AOR (95% CI)

1.03(0.86 1.25)

0.741

Reference

1.21(1.06 1.38)

0.004

1.66(1.32 2.08)

< 0.001

1st trimester

139/1315(10.6)

 

763/7106(10.7)

332/2671(12.4)

 

90/592(15.2)

 

 OR (95% CI)

0.98(0.81 1.19)

0.857

Reference

1.18(1.03 1.35)

0.018

1.49(1.18 1.89)

0.001

 AOR (95% CI)

1.07(0.88 1.30)

0.487

Reference

1.14(0.99 1.32)

0.060

1.46(1.15 1.87)

0.002

2nd trimester

8/1315(0.6)

 

74/7106(1.0)

55/2671(2.1)

 

22/592(3.7)

 

 OR (95% CI)

0.58(0.28 1.21)

0.147

Reference

2.00(1.41 2.84)

< 0.001

3.67(2.26 5.95)

< 0.001

 AOR (95% CI)

0.65(0.31 1.35)

0.243

Reference

1.74(1.22 2.48)

0.002

2.76 (1.67 4.58)

< 0.001

Ongoing pregnancy rate

1176/2527(46.5)

 

6343/13,224(48.0)

2339/5079(46.1)

 

502/1213(41.4)

 

 OR (95% CI)

0.94(0.87 1.03)

0.188

Reference

0.93(0.87 0.99)

0.020

0.77(0.68 0.86)

< 0.001

 AOR (95% CI)

0.90(0.83 0.99)

0.023

Reference

0.93(0.88 0.99)

0.046

0.76(0.67 0.86)

< 0.001

Live birth rate

1149/2527(45.5)

 

6170/13,224(46.7)

2244/5079(44.2)

 

465/1213(38.3)

 

 OR (95% CI)

0.95(0.88 1.04)

0.272

Reference

0.91(0.85 0.97)

0.003

0.71(0.63 0.80)

< 0.001

 AOR (95% CI)

0.91(0.83 0.99)

0.034

Reference

0.92(0.86 0.98)

0.013

0.70(0.62 0.80)

< 0.001

  1. Data are presented as n/n (%) for dichotomous variables
  2. OR Odd ratio, AOR adjusted odd ratio, Implantation rate was defined as the number of gestational sacs visualized on ultrasound examination divided by the number of embryos transferred. Ongoing pregnancy rate was defined as a viable pregnancy that progressed beyond 12 gestational weeks divided by the number of embryo transfer cycles for each group. Live birth rate was defined as the number of live births divided by the number of embryo transfer cycles for each group
  3. Analyses were adjusted for age, infertility duration, gravidity, parity, main cause of infertility, number of OPU prior to FET, year of treatment, number of embryo transferred, and embryo developmental stage at transfer
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BMC Medicine

ISSN: 1741-7015

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