Next-generation sequencing identifies monogenic diabetes in 16% of patients with late adolescence/adult-onset diabetes selected on a clinical basis: a cross-sectional analysis

Table 2 Clinical characteristics associated with the diagnosis of monogenic diabetes: multivariable analysis

	Monogenic vs. non-monogenic^a		Monogenic excluding GCK vs. non-monogenic		GCK only vs. non-monogenic
N: monogenic vs. non-monogenic	194 vs. 926		113 vs.926		81 vs. 926
Variable	P	OR [95% CI]	P	OR [95% CI]	P	OR [95% CI]
Sex: female vs. male	0.2866	1.22 [0.84–1.77]	0.2139	1.32 [0.85–2.05]	0.6597	1.13 [0.65–1.98]
EuroCaucasian origin: yes vs. no	< 10⁻⁴	3.83 [2.48–5.95]	< 10⁻⁴	2.70 [1.66–4.41]	< 10⁻⁴	9.17 [3.57–23.26]
N affected generations ≥ 3: yes vs. no	0.0136	1.57 [1.10–2.25]	0.0036	1.91 [1.24–2.96]	0.798	1.07 [0.63–1.81]
Age at diabetes	< 10⁻⁴	1.09 [1.07–1.11]	< 10⁻⁴	1.09 [1.06–1.11]	< 10⁻⁴	1.10 [1.06–1.13]
BMI at diabetes	< 10⁻⁴	1.13 [1.08–1.17]	0.0001	1.09 [1.04–1.14]	< 10⁻⁴	1.19 [1.11–1.27]
Symptoms of diabetes: yes vs. no	< 10⁻⁴	0.30 [0.19–0.47]	0.0036	0.48 [0.29–0.78]	< 10⁻⁴	0.06 [0.02–0.19]
AUC of the ROC analysis	0.82		0.79		0.89

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