Table 3 Main characteristics of the patients with non-monogenic diabetes, class 3 variants, and class 4–5 variants

N

1241

59

254

–

–

N inclusion criteria: 2/3

486/755

20/39

56/198

0.4949

0.0643

Sex: female/men, n (%)

619/622 (50%)

34/25 (58%)

168/86 (66%)

0.2867

0.2295

EuroCaucasian: yes/no

600/499 (55%)

28/26 (52%)

192/37 (84%)

0.7799

< 10⁻⁴

N affected generations ≥ 3, yes/no

581/631 (48%)

34/25 (58%)

144/105 (58%)

0.1818

1.0000

Age at diagnosis (years)

31 [25–39] (1239)

31 [26–37.5] (59)

24 [18–30] (254)

0.8811

< 10⁻⁴

BMI at diagnosis, kg/² (n)

24.2 [21.6–27.7] (1107)

23.7 [21.7–27.3] (51)

21.8 [20.1–24.2] (221)

0.8219

0.0007

BMI: normal/increased, n (%)

642/475 (57%)

29/23 (56%)

180/43 (81%)

0.8861

0.0005

Symptoms at diagnosis: yes/no

461/702 (40%)

15/40 (27%)

37/204 (15%)

0.0677

0.0484

HbA_1c at diagnosis, % (n)

9.6 [7–12] (588)

8.2 [6.8–11.6] (35)

6.7 [6.3–8.7] (157)

0.4888

0.0014

HbA_1c at diagnosis, mmol/mol (n)

81 [53–108]

66 [51–103]

50 [45–72]

0.4888

0.0014

Insulin therapy: yes/no

339/768 (31%)

14/37 (27%)

38/189 (17%)

0.7560

0.1098

Arterial hypertension: yes/no

214/538 (28%)

8/32 (20%)

23/133 (15%)

0.2826

0.4667

Dyslipidemia: yes/no

235/461 (34%)

12/26 (32%)

23/116 (17%)

0.8613

0.0635