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Table 1 Clinical characteristics of female RA and stroke cohorts

From: Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis

 

RA

Ischemic stroke

Low IGF1

< 140 ng/ml

High IGF1

Low IGF1

< 145 ng/ml

High IGF1

n

96

88

66

66

Age, years

59.0 [51.2–63]

47.5 p < 0.0001 [34.5–55.3]

58.5 p = 0.73 [51–66]

52.7 p = 0.004 [39.8–61.7]

Serum IGF1, ng/ml

109.5 [93–127]

182.5 p < 0.0001 [158–225]

111.6 p = 0.74 [92–127]

183 p < 0.0001 [167–223]

Height, cm

166 [161–169]

167 p = 0.041 [163–172]

163 p = 0.005 [160–167]

167 p = 0.009 [161–172]

Systolic BP, mmHg

135 [120–145]

121 p = 0.0027 [120–140]

135 p = 0.70 [120–140]

130 p = 0.114[120–140]

Diastolic BP, mmHg

80 [75–85]

80 p = 0.023 [70–80]

80 p = 0.037 [70–80]

75 p = 0.058 [70–80]

TC, mmol/L

5.6 [4.9–6.0]

5.0 p = 0.0022 [4.1–5.9]

5.1 p = 0.0004 [4.5–5.8]

4.8 p = 0.063 [4.3–5.5]

LDL, mmol/L

3.4 [2.8–4.0]

3.0 p = 0.17 [2.3–3.8]

2.8 p < 0.0001 [2.1–3.50]

2.6 p = 0.89 [2.30–3.30]

HDL, mmol/L

1.8 [1.5–2.2]

1.7 p = 0.20 [1.5–2.1]

1.6 p = 0.0002 [1.30–1.90]

1.5 p = 0.13 [1.10–1.80]

BMI, kg/m2

25.9 [23.1–29.7]

23.9 p = 0.0014 [21.9–26.7]

24.0 p = 0.17 [21.8–28.3]

24.6 p = 0.94 [22.5–28.0]

T2D, n (%)

2 (2.1%)

4 p = 0.39 (4.5%)

12 p = 0.0004 (19%)

7 p = 0.23 (9%)

Current smokers, n (%)

15 (16%)

13 p = 0.88 (16%)

32 p < 0.001 (48%)

28 p = 0.49 (45%)

Hypertension*, n (%)

25 (26%)

7 p = 0.011 (8%)

30 p = 0.012 (45%)

28 p = 0.17 (42%)

  1. IGF1 insulin-like growth factor 1, RA rheumatoid arthritis, DAS28 Disease Activity Score with assessment of 28 joints, TC total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, BMI body mass index, T2D type 2 diabetes, CVR cardiovascular risk
  2. Median [IQR], group comparison was done by unpaired t test statistics and proportions by chi-square. p values in the IGF1hi column indicate the differences between the IGF1hi and IGF1low groups; p values in the IGF1low column indicate the differences between the IGF1low groups of RA and post-stroke patients
  3. *Hypertension is defined as systolic BP ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg