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Table 1 Clinical characteristics of female RA and stroke cohorts

From: Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis

  RA Ischemic stroke
Low IGF1
< 140 ng/ml
High IGF1 Low IGF1
< 145 ng/ml
High IGF1
n 96 88 66 66
Age, years 59.0 [51.2–63] 47.5 p < 0.0001 [34.5–55.3] 58.5 p = 0.73 [51–66] 52.7 p = 0.004 [39.8–61.7]
Serum IGF1, ng/ml 109.5 [93–127] 182.5 p < 0.0001 [158–225] 111.6 p = 0.74 [92–127] 183 p < 0.0001 [167–223]
Height, cm 166 [161–169] 167 p = 0.041 [163–172] 163 p = 0.005 [160–167] 167 p = 0.009 [161–172]
Systolic BP, mmHg 135 [120–145] 121 p = 0.0027 [120–140] 135 p = 0.70 [120–140] 130 p = 0.114[120–140]
Diastolic BP, mmHg 80 [75–85] 80 p = 0.023 [70–80] 80 p = 0.037 [70–80] 75 p = 0.058 [70–80]
TC, mmol/L 5.6 [4.9–6.0] 5.0 p = 0.0022 [4.1–5.9] 5.1 p = 0.0004 [4.5–5.8] 4.8 p = 0.063 [4.3–5.5]
LDL, mmol/L 3.4 [2.8–4.0] 3.0 p = 0.17 [2.3–3.8] 2.8 p < 0.0001 [2.1–3.50] 2.6 p = 0.89 [2.30–3.30]
HDL, mmol/L 1.8 [1.5–2.2] 1.7 p = 0.20 [1.5–2.1] 1.6 p = 0.0002 [1.30–1.90] 1.5 p = 0.13 [1.10–1.80]
BMI, kg/m2 25.9 [23.1–29.7] 23.9 p = 0.0014 [21.9–26.7] 24.0 p = 0.17 [21.8–28.3] 24.6 p = 0.94 [22.5–28.0]
T2D, n (%) 2 (2.1%) 4 p = 0.39 (4.5%) 12 p = 0.0004 (19%) 7 p = 0.23 (9%)
Current smokers, n (%) 15 (16%) 13 p = 0.88 (16%) 32 p < 0.001 (48%) 28 p = 0.49 (45%)
Hypertension*, n (%) 25 (26%) 7 p = 0.011 (8%) 30 p = 0.012 (45%) 28 p = 0.17 (42%)
  1. IGF1 insulin-like growth factor 1, RA rheumatoid arthritis, DAS28 Disease Activity Score with assessment of 28 joints, TC total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, BMI body mass index, T2D type 2 diabetes, CVR cardiovascular risk
  2. Median [IQR], group comparison was done by unpaired t test statistics and proportions by chi-square. p values in the IGF1hi column indicate the differences between the IGF1hi and IGF1low groups; p values in the IGF1low column indicate the differences between the IGF1low groups of RA and post-stroke patients
  3. *Hypertension is defined as systolic BP ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg