Fig. 2

Mean haemoglobin-time profiles for a any baseline haemoglobin, b baseline ≥ 11.5 g/dL, c baseline < 11.5 g/dL and d normal G6PD status. Figures derived from the linear mixed effects model with fractional polynomial terms for time. Profiles for chloroquine (CQ) alone and chloroquine plus primaquine (CQ+PQ) adjusted to the same baseline haemoglobin. Shaded regions show 95% confidence intervals. In total, 1975 patients were treated with CQ alone and 1446 with CQ+PQ; in patients with baseline Hb ≥ 11.5 g/dL, the corresponding figures were 1277 and 1063; in patients with baseline Hb < 11.5 g/dL, the corresponding figures were 698 and 383; and in patients with normal G6PD status, the corresponding figures were 856 and 836