Fig. 1
From: When to keep it simple – adaptive designs are not always useful
Assessment of the impact of potential adaptive design limitations on different types of adaptive trial features. aAssuming no pause in recruitment; bPrimary endpoint with an intermediate observation period. Some adaptive designs were extracted from Table 1 from Pallmann et al. [2] (with the removal of dose-finding designs); MAMS have several arms and could include any of the above adaptive features at the interim stages with added complexity