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Table 3 Summary of lead SNP (LD clumped) that show suggestive associations (P < 10−5) with phenylephrine average infusion rate in a meta-analysis

From: Dissecting genetic factors affecting phenylephrine infusion rates during anesthesia: a genome-wide association study employing EHR data

Lead SNP

Coordinate (GRCh37)

A1/A2

MAF

Beta-meta (CI95)

P-PhaseI

P-PhaseII

P-meta

Gene

Upstream gene

Downstream gene

rs2069661

5:75916615

A/C

0.01725

13.85 (8.65~19.04)

5.71E−06

1.15E−02

1.80E−07

F2RL2, IQGAP2

LOC101929109

NCRUPAR

rs77080086

1:66727250

T/C

0.02468

11.07 (6.81 ~ 15.33)

5.50E−07

1.97E−01

3.51E−07

PDE4B

LOC101927139

LOC105378776

rs11572377

1:41943795

C/G

0.01689

13.00 (7.89 ~ 18.11)

5.44E−05

3.41E−03

6.09E−07

EDN2

RNA5SP45

 

rs145738725

15:25826461

A/G

0.01304

14.46 (8.49~20.42)

2.50E−04

1.44E−03

2.06E−06

 

LOC105370737

ATP10A

rs77948500

12:60298988

C/G

0.01074

− 15.85 (− 22.39~− 9.31)

1.82E−06

2.29E−01

2.06E−06

 

LOC100996696

PGBD3P1

rs148501690

6:87012360

A/G

0.01437

− 13.88 (− 19.61~− 8.15)

2.33E−03

5.65E−05

2.06E−06

 

NDUFA5P9

LOC100652960

rs4234482

3:139844245

C/G

0.26610

− 3.64 (− 5.15~− 2.14)

6.24E−04

4.11E−04

2.16E−06

CLSTN2

NMNAT3

LOC105374132

rs74400620

7:121002702

A/T

0.01364

13.98 (8.13~19.8)

1.61E−06

8.51E−01

2.83E−06

FAM3C

WNT16

CYCSP19

rs2071336

16:12061674

A/G

0.03253

8.82 (5.04~12.59)

2.41E−05

8.37E−02

4.72E−06

TNFRSF17

LOC729978

SNX29

rs76054107

5:26671351

T/C

0.02113

10.76 (6.09~15.42)

1.39E−04

1.27E−02

6.11E−06

 

MSNP1

CCNB3P1

rs16835559

3:130749602

A/C

0.01467

12.47 (6.96~17.98)

1.48E−05

2.01E−01

9.19E−06

NEK11

ASTE1

LOC339874

rs1940556

14:88661112

T/C

0.01916

− 10.95 (− 15.80~− 6.10)

9.94E−05

3.62E−02

9.58E−06

KCNK10

LOC105370612

SPATA7