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Table 2 Associations between metabolites (continuous) and risk of breast cancer, for metabolites with raw P values < 0.05

From: Prospective analysis of circulating metabolites and breast cancer in EPIC

Class

Metabolite

Odds ratio and 95% CI (for 1 SD)a

Raw P value

Permutation-based minP P valueb

Bonferroni P valuec

False discovery rate P valued

Amino acids

Arginine

0.89 (0.80–0.99)

0.035

0.753

1.000

0.166

Asparagine

0.87 (0.80–0.95)

0.002

0.109

0.240

0.062

Glutamine

0.91 (0.84–0.99)

0.031

0.731

1.000

0.166

Glycine

0.90 (0.83–0.97)

0.005

0.229

0.629

0.090

Histidine

0.91 (0.84–0.99)

0.020

0.588

1.000

0.131

Lysine

0.90 (0.83–0.98)

0.010

0.389

1.000

0.102

Threonine

0.92 (0.85–0.99)

0.034

0.752

1.000

0.166

Acylcarnitines

C14:1

1.09 (1.01–1.18)

0.028

0.704

1.000

0.166

C18:1

1.11 (1.00–1.22)

0.040

0.793

1.000

0.183

C2

1.15 (1.06–1.24)

0.0004

0.031

0.051

0.036

Glycerophospholipids

PC aa C32:3

0.90 (0.82–0.99)

0.026

0.674

1.000

0.166

PC aa C36:2

0.89 (0.82–0.97)

0.009

0.339

1.000

0.099

PC aa C36:3

0.89 (0.82–0.96)

0.002

0.117

0.272

0.062

PC aa C38:3

0.92 (0.85–0.99)

0.035

0.753

1.000

0.166

PC ae C34:2

0.90 (0.84–0.97)

0.008

0.317

0.966

0.099

PC ae C36:2

0.90 (0.84–0.98)

0.009

0.339

1.000

0.099

PC ae C36:3

0.88 (0.82–0.95)

0.001

0.044

0.073

0.036

PC ae C38:2

0.88 (0.81–0.96)

0.002

0.128

0.310

0.062

PC ae C38:3

0.90 (0.83–0.98)

0.012

0.425

1.000

0.107

PC ae C38:5

0.93 (0.86–1.00)

0.047

0.836

1.000

0.205

PC ae C40:1

0.92 (0.84–0.99)

0.030

0.730

1.000

0.166

PC ae C40:4

0.91 (0.84–0.98)

0.018

0.553

1.000

0.129

PC ae C42:1

0.90 (0.83–0.98)

0.010

0.393

1.000

0.102

lysoPC a C18:0

0.88 (0.80–0.98)

0.014

0.473

1.000

0.115

lysoPC a C18:2

0.89 (0.81–0.96)

0.004

0.209

0.559

0.090

lysoPC a C20:3

0.90 (0.83–0.98)

0.013

0.434

1.000

0.107

Sphingolipids

SM C20:2

0.90 (0.82–0.98)

0.018

0.546

1.000

0.129

SM (OH) C22:1

0.90 (0.83–0.97)

0.008

0.322

1.000

0.099

Sugars

Hexose

1.12 (1.01–1.24)

0.035

0.752

1.000

0.166

  1. SD standard deviation, CI confidence interval
  2. Italicized text indicates a statistically significant association with breast cancer risk after adjustment of P values by permutation-based minP
  3. aOdds ratios were estimated by logistic regression conditioned on center of recruitment, age, menopausal status at the time of blood collection, phase of the menstrual cycle at blood collection (for premenopausal women only), use of exogenous hormone at blood collection, time of the day at blood collection, and fasting status at blood collection
  4. bMultiple testing controlled for family-wise error rate at α = 0.05 by permutation-based stepdown minP adjustment of P values
  5. cMultiple testing controlled for family-wise error rate at α = 0.05 by Bonferroni adjustment of P values
  6. dMultiple testing controlled for false discovery rate at α = 0.05