Prospective analysis of circulating metabolites and breast cancer in EPIC

Table 3 Associations between C2 and PC ae C 36:3 and risk of breast cancer

	Cases/controls	Model 1^c	Model 2—adjusted for WC	Model 3—adjusted for weight	Model 4—adjusted for HC
	Cases/controls	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
C2
Per SD increment	1624/1624	1.15 (1.06–1.24)	1.14 (1.06–1.23)	1.15 (1.06–1.24)	1.14 (1.06–1.24)
C2 (quintiles)^a
1	287/322	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)
2	291/326	1.02 (0.81–1.28)	1.00 (0.79–1.26)	1.00 (0.80–1.27)	1.00 (0.80–1.26)
3	322/324	1.15 (0.91–1.44)	1.12 (0.89–1.41)	1.13 (0.90–1.42)	1.13 (0.89–1.42)
4	311/326	1.12 (0.89–1.41)	1.09 (0.87–1.37)	1.09 (0.87–1.37)	1.10 (0.87–1.38)
5	413/326	1.54 (1.21–1.95)	1.51 (1.19–1.91)	1.53 (1.20–1.93)	1.52 (1.20–1.93)
P trend^b		0.0002	0.0005	0.0004	0.0004
PC ae C36:3
Per SD increment	1624/1624	0.88 (0.82–0.95)	0.90 (0.83–0.97)	0.90 (0.83–0.96)	0.89 (0.83–0.96)
PC ae C36:3 (quintiles)^a
1	367/325	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)
2	363/323	0.99 (0.80–1.23)	1.01 (0.82–1.25)	1.02 (0.82–1.26)	1.02 (0.82–1.26)
3	357/326	0.96 (0.77–1.19)	0.98 (0.79–1.22)	0.98 (0.79–1.22)	0.97 (0.78–1.21)
4	264/326	0.70 (0.56–0.88)	0.73 (0.58–0.91)	0.73 (0.58–0.91)	0.72 (0.58–0.91)
5	273/324	0.73 (0.58–0.91)	0.77 (0.61–0.96)	0.76 (0.61–0.96)	0.75 (0.60–0.95)
P trend^b		0.0003	0.0020	0.0016	0.0010

CI confidence interval, HC hip circumference, OR odds ratio, SD standard deviation, WC waist circumference
^aQuintile cut-points were determined on control participants
For log-transformed C2, cut-points were as follows, in log(μmol/L): < 1.18/1.18–1.37/1.37–1.55/1.55–1.77/≥ 1.77. For log-transformed PC ae C36:3, cut-points were as follows, in log(μmol/L): < 1.81/1.81–1.94/1.94–2.04/2.04–2.16/≥ 2.16
^bFor test of linear trends across quintiles, participants were assigned the median value in each category and the corresponding variable was modeled as a continuous term
^cConditional logistic regression conditioned on matching factors

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