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Fig. 1 | BMC Medicine

Fig. 1

From: Multi-level transcriptome sequencing identifies COL1A1 as a candidate marker in human heart failure progression

Fig. 1

Flowchart for uncovering novel molecular signatures in heart failure using multi-transcriptome approach. a Clinical specimen collection and multi-level RNA sequencing. b Pipeline for mRNA, lncRNA, and microRNA (miRNA) analysis. c Construction of regulatory networks in heart failure using differentially expressed mRNAs, miRNAs, and lncRNAs. d Lasso regression analysis of the association between gene expression and fibrosis percentage in heart failure tissue. e Experimental validation of COL1A1 being associated with HF progression

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BMC Medicine

ISSN: 1741-7015

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