Fig. 2

Eleven associations between diagnosis and diffusion parameters are replicated, and their change in direction is the same. a For AxD, L-CAB, L-ILF, L-SLFT, L-SLFP, R-CAB, and R-SLFT are significantly associated with diagnosis status where AxD increased with disease severity. This is observed in ADNI3 (n = 499) and is replicated in ADNI2 (n = 210). b, c For MD and RD, bilateral CABs are associated with diagnosis status and their change in direction was consistent in two independent cohorts. d FA in bilateral CABs are associated with diagnosis status in ADNI3 but only L-CAB association is replicated in ADNI2. The change in direction is consistent between two cohorts. AxD axial diffusivity, RD radial diffusivity, MD mean diffusivity, FA fractional anisotropy, L-CAB left cingulum—angular bundle, L-ILF left inferior longitudinal fasciculus, L-SLFP left superior longitudinal fasciculus parietal, L-SLFT left superior longitudinal fasciculus temporal, R-CAB right cingulum—angular bundle, R-SLFT right superior longitudinal fasciculus temporal