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Fig. 4 | BMC Medicine

Fig. 4

From: Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer’s disease

Fig. 4

Schematic of brain region network analysis based on genetics. Tissue-to-tissue correlations (TTCs) are calculated between a pair of brain regions of interest (ROIs) for all gene combinations. Only the significant correlations are preserved (P-value < 1 × 10−8) [17] and are transformed into binary signals before bipartite clustering (see the “Methods” section for detail). This procedure is repeated for 136 possible brain region pairs (17 × 16/2). Only the bipartite modules with large number of clustered gene interactions (> 1000) are selected for each ROI producing 272 lists of genes (2 ROIs × 136). To examine how TTC genes are corroborating on shared molecular functions, pathway analysis is performed where only curated 169 pathways from PANTHER were examined. Overrepresented pathways were further analyzed (Figs. 6 and 7)

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