Fig. 8
From: Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer’s disease
Toll receptor signaling-related gene expression in the blood associate with diffusion properties in the white matter. Gene expression in the blood and dMRI scans in shared subjects were analyzed (n = 102). The transcriptome effects of toll receptor signaling pathway on a AxD, b MD, c RD, and d FA in the 18 tracts were aggregated, and its en masse effect was approximated using 100,000x permutation. In all bar plots, AD-associated tracts replicated in two cohorts are in red, and other tracts are in blue. Orange dashed line represents P-value = 0.05 threshold for significance