Heterogeneity in the uptake, attendance, and outcomes in a clinical trial of a total diet replacement weight loss programme

Table 3 Engagement of the participants enrolled into the DROPLET trial and randomised to the TDR intervention

	Low engagers¹				Engaged in weight loss phase only²				Engaged in weight loss and weight maintenance phases³
	N (%)	OR	95% CI	p	N (%)	OR	95% CI	p	N (%)	OR	95% CI	p
Total	17 (13)				11 (8)				106 (79)
Gender
Men	6 (35)	0.89	0.29, 2.66	0.823	3 (27)	0.67	0.14, 3.16	0.618	44 (42)	1.33	0.68, 1.89	0.56
Women	11 (65)				8 (72)				62 (58)
Age
≤ 44 years	7 (41)				7 (64)				34 (32)
> 44 ≤ 56 years	6 (35)	1.27	0.36, 4.52	0.728	3 (27)	0.68	0.09, 2.69	0.405	41 (39)	1.19	0.64, 2.19	0.38
> 56 years	4 (24)	1.11	0.36, 5.84	0.881	1 (9)	0.22	0.02, 2.30	0.208	31 (29)	1.60	0.78, 3.17	0.46
IMD decile
≤ 6	6 (35)	2.00	0.51, 7.89	0.322	2 (18)	0.72	0.09, 5.80	0.760	30 (28)	0.62	0.18, 2.14	0.45
> 6 ≤ 8	5 (29)	1.17	0.23, 2.82	0.814	6 (55)	2.75	0.56, 13.57	0.213	33 (31)	0.563	0.18, 1.58	0.26
> 8	6 (35)				3 (27)				43 (41)
Baseline BMI
≤ 31.8 kg/m²	2 (12)				0				15 (14)
> 31.8 ≤ 35.5 kg/m²	3 (18)	0.51	0.07, 3.49	0.494	0	–	–	–	37 (35)	2.11	0.31, 14.44	0.45
> 35.5 kg/m²	12 (71)	1.51	0.29, 7.81	0.626	11 (100)	–	–	–	54 (51)	0.31	0.06, 1.56	0.60
Type 2 diabetes
Yes	16 (94)	0.22	0.04, 2.44	0.178	1 (9)	0.53	0.05, 5.30	0.760	19 (18)	3.69	0.70, 19.39	0.12
No	1 (6)				10 (91)				87 (82)
Hypertension
Yes	14 (82)	0.83	0.17, 2.72	0.806	1 (9)	0.39	0.04, 3.95	0.426	28 (26)	1.57	0.43, 5.75	0.49
No	3 (18)				10 (91)				78 (74)

¹Attended < 6 sessions out of the possible 8 sessions during weeks 1–8, < 2 out of the possible 4 sessions offered during weeks 9–12, and < 2 out of the possible 3 sessions offered during weeks 13–26
²Attended ≥ 6 sessions out of the possible 8 sessions during weeks 1–8 only or attended ≥ 6 sessions out of the possible 8 sessions during weeks 1–8 and ≥ 2 out of the possible 4 sessions offered during weeks 9–12
³Attended 2 out of the possible 3 sessions offered during weeks 13–26

ISSN: 1741-7015