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Table 4 HRs for the incidence of hospital admission due to infection-related complications in the derivation cohort (CPRD GOLD)

From: Development and validation of a multivariable prediction model for infection-related complications in patients with common infections in UK primary care and the extent of risk-based prescribing of antibiotics

 

LRTI, HR (95% CI)

URTI, HR (95% CI)

UTI, HR (95% CI)

Age category

 < 5

2.43 (1.54–3.82)

2.20 (1.88–2.56)

10.48 (2.20–49.83)

 5–10

2.18 (1.22–3.90)

0.67 (0.54–0.83)

9.21 (1.84–46.00)

 10–15

1.30 (0.61–2.76)

0.38 (0.29–0.51)

0.88 (0.08–9.76)

 15–20

1.21 (0.57–2.56)

0.91 (0.72–1.15)

 30–40

1.35 (0.81–2.27)

1.08 (0.89–1.29)

2.00 (0.37–10.95)

 40–50

1.63 (1.00–2.65)

0.93 (0.77–1.12)

3.73 (0.79–17.61)

 50–60

1.75 (1.09–2.81)

0.93 (0.77–1.13)

4.05 (0.88–18.65)

 60–70

1.85 (1.16–2.95)

1.12 (0.92–1.36)

4.55 (1.02–20.22)

 70–80

3.18 (2.01–5.03)

1.70 (1.40–2.06)

9.78 (2.30–41.61)

 80+

5.76 (3.67–9.05)

4.82 (4.01–5.78)

15.23 (3.63–63.97)

Charlson Comorbidity Index

 2

1.05 (0.92–1.21)

1.33 (1.21–1.45)

2.08 (1.42–3.05)

 3

1.28 (1.08–1.51)

1.76 (1.53–2.01)

1.95 (1.23–3.08)

 4

1.43 (1.13–1.80)

2.27 (1.86–2.76)

4.24 (2.57–6.97)

 5

1.58 (1.15–2.16)

2.93 (2.22–3.86)

3.10 (1.53–6.27)

Ethnicity

 Combined minorities

2.12 (1.66–2.72)

1.54 (1.36–1.74)

1.03 (0.42–2.51)

Prescription (non-antibiotis) category

 Medium

1.35 (1.13–1.60)

0.86 (0.77–0.94)

2.84 (1.44–5.61)

 High

2.09 (1.71–2.57)

1.15 (1.02–1.29)

4.59 (2.22–9.51)

Gender—female

0.81 (0.73–0.89)

0.82 (0.76–0.87)

0.72 (0.56–0.94)

Flu vaccination

0.84 (0.74–0.94)

0.97 (0.88–1.06)

0.69 (0.52–0.92)

IMD quintile

 2

1.10 (0.95–1.27)

0.97 (0.88–1.07)

0.89 (0.6–1.30)

 3

1.03 (0.88–1.20)

1.06 (0.96–1.17)

0.88 (0.59–1.31)

 4

1.06 (0.91–1.24)

1.19 (1.07–1.31)

1.15 (0.78–1.69)

 5

0.87 (0.74–1.03)

1.26 (1.14–1.40)

1.29 (0.87–1.92)

Outpatient referral in previous year

1.07 (0.95–1.20)

1.25 (1.16–1.35)

0.84 (0.61–1.17)

Season

 Spring

1.05 (0.91–1.22)

0.86 (0.79–0.94)

0.81 (0.56–1.17)

 Summer

1.10 (0.94–1.30)

0.74 (0.66–0.82)

0.92 (0.64–1.31)

 Winter

1.37 (1.20–1.55)

1.03 (0.95–1.11)

1.16 (0.83–1.63)

Year of consultation

1.00 (0.98–1.01)

0.99 (0.98–1.00)

0.99 (0.96–1.02)

Hospitalisation in previous year

1.58 (1.33–1.86)

2.12 (1.85–2.43)

1.59 (1.11–2.26)