Fig. 5

The association between circulating mRNAs in maternal circulation and future stillbirth. a–c Expression levels of three circulating mRNAs among women with a live pregnancy at the time of blood sampling but later had a stillbirth. These were the last bloods taken closest to demise. d–f Serial blood samples taken from these same cases of stillbirth prior to fetal demise (one sample taken for two patients; two samples taken across 5 and 14 days for two patients; three samples taken across 10 days for one patient, and 6 bloods taken across 36 days for one patient). Red dotted line represents the median mRNA expression levels of the control group (the same controls as shown in a–c). These controls were healthy ongoing pregnancies where bloods were taken at similar gestations. *p < 0.05, **p < 0.01, ***p < 0.001. Error bars are mean ± SEM