Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Table 2 Circulating mRNAs that were differentially expressed in the maternal blood of prospective FOX cohort preterm fetal growth restriction vs healthy pregnancies identified by RNA-seq and linear regression analysis

Entrez ID	Gene symbol	logFC	Average expression	P	Adjusted P*	Selected for RT-PCR validation**
100462977	MTRNR2L1	− 2.26	3.71	4.55E−16	1.95E−12
8460	TPST1	1.39	4.43	3.90E−19	4.38E−15	Y
9509	ADAMTS2	2.99	0.36	6.09E−11	2.36E−08	Y
100505479	NA	− 1.98	1.34	2.25E−12	2.02E−09
23500	DAAM2	2.35	2.11	2.21E−11	1.13E−08	Y
144535	CFAP54	1.33	1.67	5.21E−16	1.9E−12
4549	RNR1	− 1.89	8.60	1.34E−11	7.66E−09
4550	RNR2	− 1.60	11.06	3.50E−11	1.48E−08
100463486	MTRNR2L8	− 1.51	5.15	1.26E−11	7.42E−09	Y
100462981	MTRNR2L2	− 1.26	2.47	1.17E−13	1.88E−10
100505635	LOC100505635	2.16	− 0.12	3.77E−09	7.28E−07
4929	NR4A2	1.37	0.24	5.65E−12	3.96E−09	Y
10720	UGT2B11	− 1.37	0.53	1.09E−11	6.78E−09	Y
1831	TSC22D3	0.86	8.68	3.21E−22	7.21E−18	Y
2012	EMP1	1.24	0.65	2.51E−12	2.09E−09	Y
246	ALOX15	− 1.38	1.20	1.03E−10	3.71E−08	Y
100463488	MTRNR2L10	− 1.47	− 0.34	9.47E−10	2.35E−07	Y
55301	OLAH	2.07	0.41	8.43E−08	9.38E−06	Y
11251	PTGDR2	− 0.99	2.17	2.39E−14	4.87E−11	Y
25790	CFAP45	0.99	2.82	3.48E−14	6.51E−11
5239	PGM5	1.24	1.67	1.62E−10	5.44E−08	Y

Entrez ID Entrez gene identifier, logFC log2 fold-change, AveExpr average expression, or the A value, Y Yes. *Adjusted P value corrected for the false discovery rate. **For RT-PCR validation, we selected these 13 genes because Taqman primer assays were available. The remaining eight genes we did not measure did not have Taqman primers available

ISSN: 1741-7015