Table 2 Characteristics and outcome of tuberculosis when treated with anti-PD(L)-1 or combined with anti-tuberculosis
| Â | Characteristics and outcome of tuberculosis | Tumor and active TB (n, %) | Tumor and latent TB (n, %) | Tumor and obsolete TB (n, %) |
|---|---|---|---|---|
Before anti-PD(L)-1 or anti-TB therapy | IGRA | |||
Positive | 29 (64.4) | 21 (100) | 0 | |
Negative | 7 (15.6) | 0 | 0 | |
Unknown | 9 (20.0) | 0 | 32 (100) | |
Sputum | ||||
Positive | 24 (53.3) | 0 | 0 | |
Negative | 21 (46.7) | 21 (100) | 32 (100) | |
Unknown | 0 | 0 | 0 | |
Gene Xpert | ||||
Positive | 28 (62.2) | 0 | 0 | |
Negative | 11 (24.5) | 21 (100) | 0 | |
Unknown | 6 (13.3) | 0 | 32 (100) | |
Imaging features | ||||
Secondary PTB | 39 (86.7) | 0 | 0 | |
Hematogenous PTB | 1 (2.2) | 0 | 0 | |
Tuberculous pleuritis | 5 (11.1) | 0 | 0 | |
Obsolete PTB | 0 | 0 | 32 (100) | |
Non-TB lesions | 0 | 21 (100) | 0 | |
After anti-PD(L)-1 or anti-TB therapy | Sputum conversion | |||
 Sputum negative conversion | 20 (44.4) | 0 | 0 | |
 Sputum positive conversion | 2 (4.4) | 0 | 1 (3.1) | |
 Persistent positive | 2 (4.4) | 0 | 0 | |
 Persistent negative | 21 (46.7) | 21 (100) | 0 | |
 Unknown | 0 | 0 | 31 (96.9) | |
Radiographic response | ||||
 TB absorption | 42 (93.3) | NA | 0 | |
 TB progression | 0 | NA | 1 (3.1) | |
 TB calcification | 0 | NA | 31 (96.9) | |
 Unknown | 3 (6.7) | NA | 0 | |
TB relapse or induction | ||||
 Yes | 2 (4.4) | 0 | 1 (3.1) | |
 No | 43 (95.6) | 21 (100) | 31 (96.9) | |