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Table 6 Relative risk of baby colonisation born to mothers colonised with antibiotic-resistant Escherichia coli and other resistance genes compared with non-colonised mothers

From: Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study

Outcome

Relative risk of colonisation in babies at 6–12 weeks of age by maternal colonisation status (n = 64 babies)

Unadjusted estimate

Adjusted for mode of delivery

Adjusted for gestational age at birth

Adjusted for neonatal antibiotic use

Adjusted for maternal antibiotic use

Adjusted for neonatal ICU admission

E. coli detected

1.3 (0.70, 2.47)

1.29 (0.68, 2.46)

1.35 (0.72, 2.52)

1.31 (0.70, 2.46)

1.32 (0.70, 2.49)

–

Ampicillin-resistant E. coli

1.98 (0.94, 4.16)

2.29 (1.13 ,4.64)

2.13 (1.04, 4.39)

1.91 (0.92, 3.97)

2.00 (0.95, 4.23)

–

Co-amoxiclav-resistant E. coli

1.93 (0.81, 4.58)

2.14 (0.88, 5.19)

2.24 (0.97, 5.19)

1.95 (0.84, 4.53)

1.84 (0.77, 4.40)

–

Co-trimoxazole-resistant E. coli

4.82 (1.12, 20.8)

4.44 (0.97, 20.3)

5.16 (1.21, 22.0)

4.71 (1.04, 21.4)

4.51 (1.03, 19.7)

4.55 (1.05, 19.6)

Multiple resistance in E. coli

6.50 (1.22, 34.7)

5.14 (0.99, 26.6)

6.70 (1.29, 34.8)

9.52 (1.93, 46.9)

6.39 (1.17, 34.8)

6.13 (1.15, 32.7)

TEM resistance gene

1.71 (0.96, 3.06)

1.83 (1.01, 3.33)

1.92 (1.07, 3.46)

1.89 (1.07, 3.34)

1.67 (0.91, 3.06)

1.87 (1.01, 3.46)

CTX-M resistance gene

2.00 (0.98, 4.06)

1.87 (0.88, 3.99)

1.88 (0.93, 3.79)

1.88 (0.94, 3.74)

1.92 (0.95, 3.89)

1.86 (0.92, 3.77)

  1. Empty cells correspond to analyses that failed to converge and produce estimates. Estimates are obtained through log-binomial regression models in which the presence or absence of infant carriage is modelled by the presence or absence of maternal carriage alone and the value of the specified adjustment variable. The gestational age variable is continuous, and all other variables are binomial