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Fig. 1 | BMC Medicine

Fig. 1

From: Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

Fig. 1

Anti-Spike and anti-RBD-specific antibodies at 12, 16, and 24 weeks post-infection (w.p.i.). A Blood sample collection timepoints. B Age and C sex distribution of healthy controls (HC) in comparison to mild/moderate and severe/critical COVID-19 convalescents. D Anti-Spike and E anti-RBD-specific IgG, IgG1, IgG3, IgM, and IgA titres at 12, 16, and 24 w.p.i. End point titres are reported as area under the curve (AUC). The mean is denoted by the horizontal black lines. Seronegative samples were assigned a value of 0.1. Red dashed lines represent the mean AUC + 2 SD in HC for each isotype. F–K Antibody titres subdivided by disease severity. L–M Pearson correlations between anti-Spike and anti-RBD antibody subclass titres at each timepoint. Statistical significance was assessed in B,F–K using Wilcoxon rank sum tests. ns = non-significant. * P < 0.05, ** P < 0.01, *** P < 0.001

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