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Table 2 Genomic risk loci and corresponding top variants identified by FUMA using SNPs with Pmtag < 5 × 10−8 in MTAGLBD

From: Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis

Top SNP

Genomic risk loci

Chromosome loci

n.sig

Pgwas

Pmtag

Passet

Trait subset

Variant annotion

nearestGene

rs35603727

1:155024309–156300731

1q22

11

4.06 × 10−7

2.25 × 10−21

1.67 × 10−20

LBD, PD

Intronic

UBQLN4

rs6733839

2:127839474–127894851

2q14.3

41

4.16 × 10−9

1.64 × 10−31

5.20 × 10−37

LBD, AD

Intergenic

BIN1

rs1474055

2:169091942–169166282

2q24.3

7

6.32 × 10−1

2.97 × 10−10

7.96 × 10−12

PD

Intergenic

STK39

rs10513789

3:182704808–182833363

3q27.1

27

9.88 × 10−1

1.44 × 10−12

2.15 × 10−12

PD

Intronic

MCCC1

rs34311866

4:819789–1030779

4p16.3

83

1.40 × 10−6

1.35 × 10−27

1.18 × 10−25

LBD, PD

Exonic

TMEM175

rs4389574

4:15706502–15743332

4p15.32

6

9.02 × 10−1

1.37 × 10−8

1.04 × 10−12

PD

Intronic

BST1

rs1372518

4:90513519–91127134

4q22.1

215

1.01 × 10−7

2.66 × 10−26

1.17 × 10−32

LBD, PD

UTR5

SNCA

rs1867598

5:60011636–60489094

5q12.1

16

1.21 × 10−1

4.34 × 10−9

1.87 × 10−12

LBD, PD

Intronic

ELOVL7

rs9790947

5:156506352–156568510

5q33.3

4

3.60 × 10−1

1.98 × 10−8

3.37 × 10−9

LBD, AD, PD

Intronic

HAVCR2

rs13216201

6:41140984–41166310

6p21.1

6

7.14 × 10−2

9.18 × 10−10

1.41 × 10−10

LBD, AD, PD

Intronic

TREML2

rs4731

8:11666337–11674897

8p23.1

1

2.04 × 10−2

3.09 × 10−8

6.25 × 10−8

LBD, AD, PD

Exonic

FDFT1

rs620490

8:16695418–16739127

8p22

15

5.56 × 10−1

3.41 × 10−9

4.29 × 10−9

PD

ncRNA_intronic

RP11-13N12.1

rs1532278

8:27456253–27468862

8p21.1

12

9.05 × 10−3

6.35 × 10−14

2.24 × 10−21

LBD, AD, PD

Intronic

CLU

rs11257240

10:11707563–11720620

10p14

3

9.92 × 10−2

3.60 × 10−8

6.48 × 10−11

LBD, AD, PD

Intergenic

RP11-138I18.2

rs117896735

10:121372328–121710488

10q26.1

4

9.63 × 10−1

8.46 × 10−9

1.94 × 10−9

PD

Intronic

INPP5F

rs12453

11:59856028–60041296

11q12.2

1

2.16 × 10−1

9.52 × 10−9

2.72 × 10−27

LBD, AD

Exonic

MS4A6A

rs7185007

16:30571910–31155458

16p11.2

145

6.65 × 10−3

6.10 × 10−14

1.05 × 10−11

LBD, AD, PD

Intergenic

FBXL19-AS1

rs6502490

17:15868291–16240507

17p12

1

4.13 × 10−2

4.46 × 10−8

6.19 × 10−8

LBD, PD

Intronic

NCOR1

rs2532307

17:43460181–44865603

17q21.31

1605

4.83 × 10−2

3.84 × 10−26

3.68 × 10−21

LBD, PD

Intronic

KANSL1

rs157595

19:45192348–45734751

19q13.32

185

1.58 × 10−19

4.24 × 10−145

1.39 × 10−205

LBD, AD

Intergenic

APOC1

  1. Genomic risk loci are identified by FUMA merging the LD blocks of independent significant SNPs that are closely located to each other (< 250 kb); chromosome loci represent the chromosomal regions containing genomic risk loci; n.sig represents the number of SNPs with Pmtag < 5 × 10−8 in the locus; trait subset is the optimal trait subset of top SNP identified by ASSET
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BMC Medicine

ISSN: 1741-7015

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