Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis

Table 4 Summary of colocalization results in 13 genomic risk loci

Chromosome loci	LBD-AD			LBD-PD
Chromosome loci	PP3	PP4	Best Causal	PP3	PP4	Best causal
1q22	0.0064	0.0370	rs35603727^b	0.0105	0.9893^†	rs35603727^b
2q14.3	0.0002	0.9998^a	rs4663105	0.0198	0.1529	rs4663105
4p16.3	0.0213	0.4839	rs34311866^b	0.0023	0.9976^a	rs34311866^b
4q22.1	0.0432	0.5154	rs7680557	1.0000^a	0.0000	rs356203
5q12.1	0.0001	0.0012	rs4647170	0.0212	0.3983	rs75646569
5q33.3	0.0023	0.1630	rs6555853	0.0002	0.0168	rs9790947^b
6p21.1	0.0014	0.2463	rs34346157	0.0002	0.0602	rs13216201^b
8p21.1	0.0009	0.8264^a	rs1532278^b	0.0000	0.0400	rs1532276
10p14	0.0012	0.4398	rs7920721	0.0000	0.0021	rs11257240^b
11q12.2	0.0070	0.2948	rs7926354	0.0001	0.0033	rs11512743
16p11.2	0.0809	0.7554^a	rs889555	0.1608	0.7843^a	rs8050588
17q21.31	0.1041	0.4977	rs2532276	0.1068	0.5140	rs58879558
19q13.32	0.0208	0.9792^a	rs114536010	0.0277	0.0984	rs157595^b

LBD Lewy body dementia, AD Alzheimer’s disease, PD Parkinson’s disease, PP posterior probability; PP3 PP of both traits are associated but with distinct causal variants, PP4 PP of both traits are associated and share a single causal variant, Best causal SNP with the highest PP4 is considered to be the causal variant in the genomic risk loci
^aPP3 or PP4 larger than 0.75
^bThe potential causal SNP was the top SNP in the locus

ISSN: 1741-7015