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Fig. 3 | BMC Medicine

Fig. 3

From: A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension

Fig. 3

eQTL analysis, gene expression profiling analysis, and RT-qPCR assay identified the low expression of SDC3 was associated with aTRH. A Directional effects of the four suggestive loci from the GTEx portal (https://www.gtexportal.org/home/). B, C The eQTL plots of the rs7542771 in 1p35 were downloaded from the GTEx portal. Numbers below the genotypes indicate sample size. eQTL P values are indicated. D The eQTL plots of the rs1432330 in 4q13.2-21.1 were downloaded from the GTEx portal. Numbers below the genotypes indicate sample size. eQTL P values are indicated. E Peripheral blood gene expression profiling analysis results of SDC3, LAPTM5, and UGT2B4 were detected by Affymetrix Human Gene 2.0ST Array in 17 aTRHs, 13 controls, and 9 hypertensives. The error bar indicated 1 SD from the mean. Two tailed t test was used for comparison between two groups. F The expression difference of SDC3 was further verified by quantitative polymerase chain reaction experiments in peripheral blood from our previous cohort. The expression of SDC3 in aTRHs was significantly lower when compared with controls or hypertensives (52 vs 87/87)

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