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Table 1 Suggestive associations (P < 1E−5) observed for aTRH

From: A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension

CHR

SNP

Imputed or genotyped

BP

RA

NRA

OR

L95

U95

P value

Nearest gene

MAF-case

MAF-control

1p35

rs7542771

Imputed

31237122

T

C

0.588

0.465

0.743

8.76E−06

LAPTM5-SDC3

0.150

0.210

1p35

rs10798802

Imputed

31243913

T

C

0.578

0.456

0.732

5.30E−06

0.147

0.209

1p35

rs11299707

Imputed

31246659

AC

A

0.586

0.464

0.742

8.33E−06

0.150

0.211

1p35

rs878465

Imputed

31247089

A

G

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs10798803

Imputed

31247334

A

C

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs10798804

Imputed

31247358

T

C

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs6668307

Imputed

31247514

G

T

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs6659862

Imputed

31247540

T

C

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs4949297

Imputed

31247674

C

A

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs4949179

Imputed

31247811

A

T

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs4949298

Imputed

31247991

A

G

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs10798805

Imputed

31248289

G

T

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs10753235

Imputed

31248432

A

C

0.588

0.465

0.744

9.34E−06

0.150

0.211

1p35

rs10753236

Imputed

31248435

G

T

0.588

0.465

0.744

9.34E−06

0.150

0.211

4q13.2-21.1

rs1432330

Imputed

70513551

G

A

1.553

1.290

1.869

3.33E−06

UGT2A1

0.414

0.342

4q13.2-21.1

rs4148279

Genotyped

70514358

C

T

1.563

1.298

1.884

2.61E−06

0.412

0.340

4q13.2-21.1

rs4148277

Imputed

70514829

T

A

1.560

1.295

1.879

2.75E−06

0.413

0.342

4q13.2-21.1

rs7672805

Imputed

70516520

G

A

1.560

1.295

1.879

2.75E−06

0.413

0.342

4q13.2-21.1

rs10000435

Imputed

70516671

C

T

1.563

1.297

1.884

2.71E−06

0.417

0.343

4q13.2-21.1

rs1432332

Imputed

70517108

C

T

1.580

1.311

1.905

1.61E−06

0.416

0.341

5q22-23.2

rs1876648

Genotyped

121027720

A

G

1.581

1.318

1.898

8.38E−07

LOC102467226-FTMT

0.475

0.394

5q22-23.2

rs10056108

Imputed

121028770

A

T

1.571

1.309

1.886

1.24E−06

0.476

0.396

15q11.1-q12

rs7181789

Genotyped

23043896

A

G

1.529

1.273

1.837

5.45E−06

NIPA1

0.487

0.423

  1. Chr chrom genome version of CRCh37/hg19, Chr chromosome, SNP single-nucleotide polymorphism, BP base position, RA risk allele, NRA non-risk allele, OR odds ratio, L95 lower 95% limit, U95 upper 95% limit, MAF Minor allele frequency
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BMC Medicine

ISSN: 1741-7015

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